Prognostic value of cardiovascular magnetic resonance T1 mapping and extracellular volume fraction in nonischemic dilated cardiomyopathy

Table 2 CMR parameters—univariate analysis in the prediction of HF- and arrhythmia-related events

	HF-related events (n = 42)				Arrhythmia-related events (n = 16)
	OR	95% CI^a	p-value^*	AUC (%)^b	OR	95% CI^a	p-value^*	AUC (%)^b
HR	1.02	1.00–1.04	0.087	60.8	1.01	0.98–1.05	0.587	56.1
LVEF	0.93	0.89–0.97	< 0.001	69.8	0.97	0.92–1.03	0.281	58.5
LVEF > optimal cutoff^c	0.21	0.10–0.45	< 0.001	68.3	0.42	0.12–1.54	0.191	58.3
LVEDV	1.01	1.00–1.01	0.032	63.0	1.00	0.99–1.01	0.479	56.1
LV mass	1.00	0.99–1.02	0.728	54.9	1.00	0.98–1.02	0.830	48.6
LGE presence	1.94	0.96–3.93	0.066	58.1	2.46	0.82–7.40	0.109	60.8
Native T1 Z-score	1.22	1.04–1.42	0.014	64.0	1.27	1.02–1.59	0.035	68.9
Native T1 Z-score > optimal cutoff^d	3.00	1.46–6.20	0.003	62.8	3.41	1.20–9.70	0.022	63.7
ECV global	1.17	1.07–1.28	0.001	66.1	1.13	0.99–1.29	0.070	65.0
Base ECV	1.11	1.02–1.20	0.011	61.9	1.08	0.96–1.22	0.206	59.0
Mid-ECV	1.14	1.05–1.23	0.001	65.7	1.05	0.93–1.19	0.409	57.4
Apex ECV	1.07	0.99–1.16	0.077	55.9	1.12	0.99–1.26	0.076	65.4
ECV > optimal cutoff^e	3.56	1.66–7.64	0.001	62.3	3.58	1.21–10.61	0.022	65.2
ECV maximum	1.10	1.04–1.17	0.002	62.9	1.07	0.98–1.18	0.139	61.5

Bold values indicate significant p value (p ≤ 0.05)
HF heart failure, CMR cardiac magnetic resonance imaging, HR heart rate, LVEF left ventricular ejection fraction, LVEDV left ventricular end-diastolic volume, LV left ventricular, NYHA New York Heart Association, LGE late gadolinium enhancement, ECV extracellular volume fraction
*P ≤ 0.05 is considered significant
^aOdds ratios with 95% confidence intervals (univariate logistic regression)
^bArea under the ROC curve
^cThe Youden index was used to depict optimal cutoff values from the ROC curves (27.8 for MACE, 27.8 for heart failure and 34.0 for arrhythmia)
^dThe Youden index was used to depict optimal cutoff values from the ROC curves (4.0 for MACE, 3.8 for heart failure and 4.2 for arrhythmia)
^eThe Youden index was used to depict optimal cutoff values from the ROC curves (30.1 for MACE, 32.1 for heart failure and 30.5 for arrhythmia)

ISSN: 1532-429X