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Table 2 Localized peak strain and systolic strain rate derived from 3D + time CMR

From: Localized strain characterization of cardiomyopathy in Duchenne muscular dystrophy using novel 4D kinematic analysis of cine cardiovascular magnetic resonance

Strain

Region

Peak Strain Value

Systolic Strain Rate

Control

(n = 25)

DMD CMP

(n = 25)

p

AUC

Control

(n = 25)

DMD CMP

(n = 25)

p

AUC

Circumferential

(Ecc)

Basal

 − 22.5 ± 2.4

 − 17.9 ± 4.3*

0.010

0.83 [0.71–0.95]

 − 1.6 ± 0.2

 − 1.1 ± 0.1*

 < 0.001

0.95 [0.89–1.00]

Mid

 − 22.6 ± 3.8

 − 20.0 ± 4.8*

0.452

0.66 [0.51–0.81]

 − 1.6 ± 0.3

 − 1.3 ± 0.2*

0.001

0.81 [0.69–0.93]

Apical

 − 27.3 ± 5.1

 − 24.0 ± 5.7*

0.054

0.68 [0.53–0.83]

 − 1.9 ± 0.3

 − 1.6 ± 0.4*

 < 0.001

0.82 [0.70–0.93]

Global

 − 24.2 ± 3.1

 − 20.6 ± 4.5*

0.080

0.75 [0.61–0.88]

 − 1.7 ± 0.2

 − 1.3 ± 0.2*

 < 0.001

0.89 [0.80–0.98]

Longitudinal

(Ell)

Anterior FW

 − 11.2 ± 2.4

 − 10.3 ± 2.8

0.998

0.55 [0.39–0.71]

 − 0.7 ± 0.2

 − 0.6 ± 0.1*

0.174

0.7 [0.56–0.85]

Anterior

 − 10.8 ± 2.2

 − 10.3 ± 2.9

0.999

0.53 [0.36–0.69]

 − 0.7 ± 0.1

 − 0.6 ± 0.1*

0.256

0.69 [0.55–0.84]

Anterior S

 − 9.6 ± 2.1

 − 9.0 ± 2.9

0.999

0.57 [0.40–0.73]

 − 0.6 ± 0.2

 − 0.5 ± 0.1

0.799

0.66 [0.50–0.81]

Posterior S

 − 9.7 ± 2.5

 − 9.1 ± 2.5

0.999

0.6 [0.44–0.76]

 − 0.6 ± 0.2

 − 0.5 ± 0.1

0.875

0.64 [0.48–0.80]

Posterior

 − 11.8 ± 2.3

 − 10.2 ± 3.2

0.655

0.66 [0.51–0.82]

 − 0.7 ± 0.2

 − 0.6 ± 0.1*

0.058

0.72 [0.57–0.86]

Posterior FW

 − 11.5 ± 2.6

 − 10.1 ± 2.9

0.753

0.64 [0.49–0.80]

 − 0.7 ± 0.2

 − 0.6 ± 0.1*

0.019

0.79 [0.66–0.92]

Global

 − 10.8 ± 1.8

 − 9.8 ± 2.6

0.995

0.61 [0.45 − 0.77]

 − 0.7 ± 0.1

 − 0.6 ± 0.1*

0.262

0.73 [0.59–0.88]

Radial

(Err)

Basal

41.9 ± 12.8

21.1 ± 12.0*

 < 0.001

0.88 [0.79–0.97]

2.8 ± 1.1

0.8 ± 0.8*

 < 0.001

0.88 [0.79–0.97]

Mid

33.6 ± 13.7

19.4 ± 11.1*

0.001

0.79 [0.67–0.91]

2.3 ± 0.9

0.9 ± 0.8*

 < 0.001

0.83 [0.72–0.94]

Apical

25.4 ± 12.3

15.3 ± 10.2*

0.054

0.75 [0.62–0.89]

1.4 ± 0.7

0.5 ± 0.7*

0.052

0.8 [0.68–0.92]

Global

33.7 ± 11.4

18.7 ± 10.3*

 < 0.001

0.84 [0.73–0.95]

2.2 ± 0.8

0.8 ± 0.7*

 < 0.001

0.88 [0.79–0.97]

Surface Area

(Ea)

Basal

 − 31.6 ± 3.2

 − 25.4 ± 5.2*

0.009

0.85 [0.74–0.96]

 − 2.2 ± 0.3

 − 1.5 ± 0.2*

 < 0.001

0.96 [0.90–1.0]

Mid

 − 31.3 ± 4.7

 − 27.3 ± 6.3*

0.293

0.68 [0.53–0.83]

 − 2.1 ± 0.3

 − 1.7 ± 0.2*

 < 0.001

0.84 [0.73–0.95]

Apical

 − 38.6 ± 6.8

 − 35.1 ± 8.6

0.232

0.62 [0.47–0.78]

 − 2.7 ± 0.5

 − 2.3 ± 0.5*

 < 0.001

0.79 [0.66–0.91]

Global

 − 33.6 ± 4.1

 − 29.2 ± 6.2*

0.106

0.72 [0.58–0.86]

 − 2.3 ± 0.3

 − 1.8 ± 0.2*

 < 0.001

0.9 [0.82–0.99]

  1. FW, free-wall; S, septal; DMD, CMP Duchenne muscular dystrophy-associated cardiomyopathy; AUC, area under the curve. *p < 0.05 (Tukey multiple comparisons adjusted)
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Journal of Cardiovascular Magnetic Resonance

ISSN: 1532-429X

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