Cardiovascular magnetic resonance-derived left atrioventricular coupling index and major adverse cardiac events in patients following acute myocardial infarction

Table 3 Univariate and multivariate Cox regression analysis for prediction of MACE

Variables	Univariate Hazard ratio (CI)	p-value	Multivariate Hazard ratio (CI)	p-value
Age	1.04 (1.02–1.06)	< 0.001	1.02 (0.99–1.04)	0.12
Hypertension	0.47 (0.25–0.88)	0.017	0.67 (0.34–1.33)	0.25
Diabetes	0.58 (0.36–0.94)	0.026	0.79 (0.47–1.34)	0.38
Heart rate (bpm)	1.03 (1.01–1.04)	< 0.001	1.01 (1.0–1.03)	0.051
Killip class on admission	2.02 (1.59- 2.56)	< 0.001	1.5 (1.1–2.0)	0.006
Number of diseased vessels	1.5 (1.1–2.0)	0.004	1.24 (0.91–1.69)	0.18
Infarct size (ml)	1.0 (1.0–1.02)	0.015	0.99 (0.99–1.01)	0.84
LVEF (%)	0.94 (0.92–0.96)	< 0.001	0.96 (0.93–0.98)	< 0.001
LACI (%) ^†	8.1 (3.4–19.7)	< 0.001	3.1 (1.0–9.4)	0.049
LV EDVI (mL/m²)^†	1.01 (1.0–1.02)	0.07	1.0 (0.98–1.01)	0.99
LV ESVI (mL/m²)^†	1.03 (1.02–1.04)	< 0.001	1.0 (0.98–1.02)	0.74
GLS (%) *	1.14 (1.1–1.2)	< 0.001
LA EDVI (mL/m²)^†	1.01 (1.0–1.02)	< 0.001	1.02 (1.0–1.03)	0.02
LA ESVI (mL/m²)^†	1.02 (1.01–1.03)	< 0.001	1.01 (0.99–1.03)	0.08
LA Total strain (%) *	0.91 (0.87–0.94)	< 0.001

^† Due to high correlations of LA and LV volumes with LACI, only LACI or sole LA or LV volumes were included to multivariate regression models
* LV GLS and LA total strain were not included to the presented multivariate regression models due to their outperforming associations with MACE compared to LACI and LV ejection fraction (LVEF)
EDVI: end-diastolic volume index, ESVI: end-systolic volume index, GLS: global longitudinal strain, LA: left atrial, LACI: left atrioventricular coupling index, LVEF: left ventricular ejection fraction

ISSN: 1532-429X