Reference left atrial dimensions and volumes by steady state free precession cardiovascular magnetic resonance
© Maceira et al; licensee BioMed Central Ltd. 2010
Received: 5 July 2010
Accepted: 11 November 2010
Published: 11 November 2010
Left atrial (LA) size is related to cardiovascular morbidity and mortality. Cardiovascular magnetic resonance (CMR) provides high quality images of the left atrium with high temporal resolution steady state free precession (SSFP) cine sequences. We used SSFP cines to define normal ranges for LA volumes and dimensions relative to gender, age and body surface area (BSA), and examine the relative value of 2D atrial imaging techniques in patients.
For definition of normal ranges of LA volume we studied 120 healthy subjects after careful exclusion of cardiovascular abnormality (60 men, 60 women; 20 subjects per age decile from 20 to 80 years). Data were generated from 3-dimensional modeling, including tracking of the atrioventricular ring motion and time-volume curves analysis. For definition of the best 2D images-derived predictors of LA enlargement, we studied 120 patients (60 men, 60 women; age range 20 to 80 years) with a clinical indication for CMR.
In the healthy subjects, age was associated with LA 4-chamber transverse and 3-chamber anteroposterior diameters, but not with LA volume. Gender was an independent predictor of most absolute LA dimensions and volume, but following normalization to BSA, some associations became non-significant. CMR normal ranges were modeled and are tabled for clinical use with normalization, where appropriate, for BSA and gender and display of parameter variation with age. The best 2D predictors of LA volume were the 2-chamber area and 3-chamber area (both r = 0.90, p < 0.001).
These CMR data show that LA dimensions and volume in healthy, individuals vary significantly by BSA, with lesser effects of age and gender.
Left atrial (LA) size represents the integration of LV diastolic performance over time and is considered a reliable indicator of the duration and severity of diastolic dysfunction , regardless of whatever loading conditions are present at the time of the examination. It provides significant prognostic information both in the general population and in patients with heart disease including heart failure [2–4], acute myocardial infarction [5–8], cardiomyopathy [9, 10], and mitral regurgitation . LA enlargement is commonly found in hypertensive heart disease [12, 13] and it is a risk factor for atrial fibrillation and stroke, especially in men [14, 15], and for atrial fibrillation recurrence following therapy [16, 17]. In the clinical setting, LA diameters and areas are usually measured, though LA volume is a more robust marker of cardiovascular events . Cardiovascular magnetic resonance (CMR) has been applied for the measurement of left and right ventricular volumes, systolic function and mass for many years in the clinical arena, with standardized methods of short axis multi-slice acquisition . The excellent accuracy and reproducibility of CMR is well established , making it a gold standard technique for measurement of ventricular dimensions and function, for which reference ranges have been established from the Steady State Free Precession (SSFP) technique [21, 22]. SSFP yields excellent blood-endocardium and epicardium-fat contrast, higher acquisition speed, and the ability to greatly improve the temporal resolution of the cines without loss of image quality . However, atrial dimensions have not been extensively studied with CMR, and there is limited data on the influences of age, gender and body surface area (BSA) on atrial dimensions. Therefore, the aim of this study was to establish SSFP based reference values in normal subjects for LA dimensions normalized, when necessary, for independent influences such as gender, body surface area and age. It was also our aim to determine the best predictors of LA enlargement among 1D and 2D parameters. Finally, we produced an equation for simplified estimation of LA volume from LA diameters and areas easily obtained in a clinical setting.
Baseline characteristics of the healthy subjects and the patient group (mean ± SD)
49 ± 17
65 ± 12
171 ± 9
163 ± 9
72 ± 13
77 ± 13
Body surface area [m2]
1.83 ± 0.18
1.83 ± 0.18
Body mass index [kg/m2]
24 ± 4
29 ± 5
Heart Rate [bpm]
66 ± 10
70 ± 14
Systolic blood pressure [mmHg]
124 ± 12
141 ± 26
Diastolic blood pressure [mmHg]
73 ± 7
77 ± 15
Ischemic heart disease
Coronary risk factors
Hypertensive heart disease
Valvular heart disease
Congenital heart disease
Arrhythmogenic right ventricular cardiomyopathy
CMR was performed with 1.5T scanners (Siemens Sonata and Avanto) using front and back surface coils and retrospective ECG triggering for capture of the entire cardiac cycle including diastole. All CMR scans were acquired by the same operator. SSFP end-expiratory breath-hold cines were acquired in the 2, 4 and 3 chamber views, with subsequent contiguous short-axis cines from the atrioventricular (AV) ring to the base of the atria. Slice thickness was 5 mm with no gap between slices. The temporal resolution was 21 ± 1 ms. Sequence parameters included repetition time/echo time of 3.2/1.6 ms, in-plane pixel size of 2.1 × 1.3 mm, flip angle 60°, and acquisition time of typically 18 heartbeats.
All atrial parameters were found to satisfy a normal distribution using the Kolmogorov-Smirnov test and summary data for these variables are therefore presented as mean ± SD. The interobserver variability was measured in a subset of 20 subjects for all variables. Simple linear regression was used to model the data and to construct reference ranges as mean and 95% confidence intervals. Two-way ANOVA was used to analyze variations in parameters due to age and gender. P values < 0.05 were considered significant. In the patient group correlations of 1D and 2D parameters with LA volume were assessed with the Pearson's coefficient. Logistic regression analysis was used to define the best predictors of LA enlargement among 1D and 2D parameters. Linear regression analysis was used to predict LA volume.
Baseline characteristics and summary results
Healthy subjects-Left atrial summary data for all ages (mean, 95% confidence interval)
Volume [mL] SD 14.9 *
Volume/BSA [mL/m2] SD 6.7
Area - 4ch [cm2] SD 3.7 *
Area/BSA - 4ch [cm2/m2] SD 1.8 *
Longitudinal diameter - 4ch[cm] SD 0.7 *
Longitudinal diameter/BSA - 4ch[cm/m2] SD 0.4 *
Transverse diameter - 4ch [cm] SD 0.5
Transverse diameter/BSA - 4ch [cm/m2] SD 0.3 *
Area - 2ch [cm2] SD 4.7 *
Area/BSA - 2ch [cm2/m2] SD 2.4
Longitudinal diameter - 2ch[cm] SD 0.7 *
Longitudinal diameter/BSA - 2ch[cm/m2] SD 0.4
Transverse diameter - 2ch [cm] SD 0.5 †
Transverse diameter/BSA - 2ch [cm/m2] SD 0.2 * †
Area - 3ch [cm2] SD 3.6 * †
Area/BSA - 3ch [cm2/m2] SD 1.8 †
AP diameter - 3ch [cm] SD 0.5 †
AP diameter/BSA - 3ch [cm/m2] SD 0.3 * †
Healthy subjects-Left atrial parameters significantly influenced by age on multivariable analysis (mean, 95% confidence interval)
Transverse diameter - 2ch [cm] SD 0.5
AP diameter-3ch [cm] SD 0.6
Area/BSA-3ch [cm] SD 1.8
Transverse diameter/BSA-2ch [cm] SD 0.2
AP diameter/BSA-3ch [cm] SD 0.3
Area-3ch [cm] SD 3.8
Transverse diameter/BSA-2ch [cm] SD 0.3
AP diameter/BSA-3ch [cm] SD 0.3
Area-3ch [cm] SD 3.4
Influence of body surface area on atrial parameters
BSA was significantly higher in males than in females (p < 0.001). On multivariate analysis, BSA was found to have significant independent influence on all LA parameters except for the longitudinal and transverse diameters in the 4-chamber view.
Influence of age on atrial parameters
No significant increase in LA volume with age was observed. On univariable analysis there was a significant decrease in absolute and normalized transverse diameters (measured in the 2-chamber view) (p = 0.038, p = 0.008, respectively), and in absolute and normalized anteroposterior diameters (both p < 0.001) with increasing age. On multivariable analysis, age was an independent predictor of absolute and normalized transverse diameters (measured in the 2-chamber view) (p = 0.022 and p = 0.004, respectively) and of absolute and normalized anteroposterior diameters and areas (measured in the 3-chamber view) (diameters p = 0.001 and p = 0.001, areas p = 0.005 and p = 0.006). Age was not an independent predictor of LA volume. Variables with significant differences according to age in the multivariable analysis are depicted with age breakdown in table 3.
Influence of gender on atrial parameters
All absolute LA volume, diameters and areas were significantly larger in males (all p < 0.05) except transverse diameters (2-chamber and 4-chamber views) and anteroposterior diameter, which did not show significant differences. When parameters were normalized to BSA, only longitudinal (4-chamber view), transverse (2 and 4-chamber views) and anteroposterior diameters showed differences, being all of them higher in females (all p < 0.01). On multivariable analysis, gender had significant independent influence on absolute longitudinal diameters (2-chamber and 4-chamber), areas (2-chamber, 3-chamber, 4-chamber views) and volume, and on normalized longitudinal (4-chamber), transverse (2-chamber and 4-chamber) and anteroposterior diameters and area (4-chamber view) (all p < 0.01).
Predictors of atrial enlargement
Predictors of left atrial enlargement according to normalized LAV
Univariable analysis: Measurements
Longitudinal diameter-4ch (> 7 cm)
Transverse diameter-4ch (> 5.1 cm)
Area-4ch (> 28 cm2)
Longitudinal diameter-2ch (> 6.3 cm)
Transverse diameter-2ch (> 5.6 cm)
Area-2ch (> 29 cm2)
AP diameter-3ch (> 4.2 cm)
Area-3ch (> 25 cm2)
Longitudinal diameter/BSA-4ch (> 3.9 cm/m2)
Transverse diameter/BSA-4ch (> 2.8 cm/m2)
Area/BSA-4ch (> 15 cm2/m2)
Longitudinal diameter/BSA-2ch (> 3.2 cm/m2)
Transverse diameter/BSA-2ch (> 2.9 cm/m2)
Area/BSA-2ch (> 16 cm2/m2)
AP diameter/BSA-3ch (> 2.3 cm/m2)
Area/BSA-3ch (> 13 cm2/m2)
Multivariable analysis: Normalized measurements
Area/BSA-4ch (> 15 cm2/m2)
Transverse diameter/BSA-4ch (> 2.8 cm/m2)
Estimation of LA volume from 2D based dimensions in the patient group
Correlations of 1D and 2D parameters with left atrial volume (Pearson's coefficient)
Longitudinal diameter -4ch
Transverse diameter -4ch
Longitudinal diameter -2ch
Transverse diameter -2ch
AP diameter -3ch
Predictors of absolute left atrial volume
Univariable analysis: Measurements
Longitudinal diameter -4ch [cm]
Transverse diameter -4ch [cm]
Area -4ch [cm2]
Longitudinal diameter -2ch [cm]
Transverse diameter -2ch [cm]
Area -2ch [cm2]
AP diameter -3ch [cm]
Area -3ch [cm2]
Longitudinal diameter/BSA -4ch [cm/m2]
Transverse diameter/BSA -4ch [cm/m2]
Area/BSA -4ch [cm2/m2]
Longitudinal diameter/BSA -2ch [cm/m2]
Transverse diameter/BSA -2ch [cm/m2]
Area/BSA -2ch [cm2/m2]
AP diameter/BSA -3ch [cm/m2]
Area/BSA -3ch [cm2/m2]
Multivariable analysis: Absolute measurements
Area -3ch [cm2]
Area -4ch [cm2]
AP diameter -3ch [cm]
Transverse diameter -2ch [cm]
Transverse diameter -4ch [cm]
Where LAV is LA volume (mL), A3 is area in the three-chamber view, A4 is area in the four-chamber view (both in cm2), TD2 is transverse diameter in the two-chamber view, TD4 is transverse diameter in the four-chamber view and APD is anteroposterior diameter (all in cm).
This current study provides normal reference ranges for atrial dimensions using modern CMR acquisition techniques and analysis for a healthy population which has been very well characterized for the absence of hypertension, significant coronary disease and heart failure. CMR is now considered a gold standard clinical technique to measure atrial and ventricular volumes and function, so these data have significant clinical utility. The tables of results include all 1D and 2D parameters as well as LA volume and are divided into males/females or all subjects, and in age deciles, when appropriate, or all ages, in order to have applicability for comparison with any other future research data set. For all ages and genders, a volume of 102 mL (53 mL/m2) was obtained as the upper limit of normality. With regard to areas, the upper limits of normality were 28 cm2 (15 cm2/m2) in the four chamber view, 29 cm2 (16 cm2/m2) in the 2-chamber view and 25 cm2 (13 cm2/m2) in the 3-chamber view. The upper limits of normality for diameters in the 4-chamber and 2-chamber views were longitudinal 7.0 cm (3.9 cm/m2) and 6.3 cm (3.2 cm/m2), transverse 5.1 cm (2.8 cm/m2) and 5.6 cm (2.9 cm/m2) respectively, and an anteroposterior diameter of 4.2 cm (2.3 cm/m2) in the 3-chamber view.
Other authors have published reference ranges for atrial dimensions with CMR but we have not found any other study in which all 1D, 2D and 3D parameters were measured with CMR. Several studies in the past addressed LA dimensions with spin-echo sequences that are not comparable with the current steady state free precession sequences that we used. Hudsmith et al , using the biplane area-length method, established values of volume similar to ours, 97 ± 27 mL for all subjects, 103 ± 30 mL for males and 89 ± 21 mL for females, with differences probably due to the need for geometric assumptions with that method. Sievers et al , published reference diameters for the 2, 4 and 3-chamber views slightly lower than ours, probably due to the fact that they used prospective triggering, which yields lower values, as reported by the same authors . Anderson et al  published that a LA area < 24 cm2 and a depth < 5.8 cm included the upper 95th percentile of the normal range. Therkelsen et al  obtained higher values in a small group of 19 volunteers, with a mean LA volume of 62 mL/m2.
We observed that nearly all non-indexed 1D, 2D and 3D parameters were significantly higher in males, except for transverse diameters in the 2 and 4 chamber views and the anteroposterior diameter in the 3-chamber view, while these differences disappeared in most normalized parameters, though some of them even turned out to be higher in females. Hudsmith et al  also reported higher absolute LA volumes in males with similar ejection fraction between the two genders. Similarly, Sievers et al observed higher diameters in the 2 and 4-chamber views in males with no differences in the anteroposterior diameter .
With respect to age, we found no differences in LA volume with increasing age in this group of healthy, normotensive individuals, and only six 1D and 2D parameters showed significant differences: absolute and normalized transverse diameter in the 2-chamber view and absolute and normalized anteroposterior diameter and area the 3-chamber view. This finding is in accord with previous reports [33, 34] and could indicate that age causes a certain degree of atrial remodeling without significant atrial dilatation. The LA is exposed to left ventricular diastolic pressure and, because of its thin walls, tends to dilate when pressure increases. Our healthy population was normotensive, with no signs of coronary artery disease, cardiomyopathy - the main causes of significant diastolic dysfunction - or valvular heart disease. Thus, our aged healthy volunteers were very likely to have just a mild degree of diastolic dysfunction, the so-called stage 1, with no increased filling pressures and no concomitant LA dilatation. Diastolic function parameters derived from ventricular time-volume curves in this healthy population have been published elsewhere . Concordantly, Thomas et al  measured LA volume by 3D echocardiography in 92 healthy subjects and found that normal aging does not increase LA size. Sievers et al  compared volunteers less than 50 years with those over that age and observed no significant differences. Germans et al , comparing 19 healthy subjects between 20-40 years versus another 19 between 40-65 years, found that maximum LA volume tended to be larger in the older group, but this difference did not reach statistical significance. They obtained values for LA volume slightly higher than ours, approximately 50 ± 7 mL/m2. Of note, they excluded subjects with hypertension defined as systolic blood pressure ≥160 mmHg and/or diastolic blood pressure ≥90 mmHg, which means that subjects with mild hypertension could have been included who had higher LA volumes.
Comparison with echocardiographic studies and other imaging techniques
Since CMR does not require for geometric assumptions to measure LA volume and allows inclusion of the LA appendage into the volume measurement, LA volume measured by retrogated CMR is said to be larger than the reference values obtained with 1D and 2D echocardiography, mainly by the area-length, Simpson's and prolate ellipsoid methods. Ukino et al  reported reference LA volumes that ranged from 39 ± 14 mL/m2 by the area-length method to 32 ± 14 mL/m2 by the prolate-ellipsoid method, smaller than our values. Currently, 3D echo is the preferred echocardiographic technique for measuring LA volume because of its higher accuracy. Keller et al  showed that 3D echo had the highest correlation and lowest bias compared to CMR, with a mild underestimation of volume of 5.3 mL. Artang et al  have recently found a systematic underestimation of LA volumes with 3D echo when compared to CMR, of 15-20 mL, that could be due to the higher spatial resolution of CMR which permits more accurate border detection and better delineation of volumes within the trabeculae. Also, the lower temporal resolution of 3D echo may account for these differences.
Cardiac computed tomography (CCT) has also been used to measure LA volume, with published reference values higher than the ones reported in our study. Lin et al  measured LA volume with CCT in 103 healthy normotensive volunteers and obtained a reference value of 102 ± 48 mL. Likewise, Mahabadi et al  studied 96 patients in whom mean LA volume was 90 ± 25 mL. The reason for this disparity of results might be the characteristics of the patients recruited, as the ones in the study from Mahabadi were a subset of the Rule Out Myocardial Infarction using Computer Assisted Tomography trial.
Predictors of LA enlargement and estimators of LA volume
Though measurement of LA volume is desirable, it may be too time-consuming for daily clinical practice. Therefore, 1D and 2D parameters might be a valuable tool to assess LA size. The best independent indicators of LA enlargement in our study were an area > 15 cm2/m2 and a transverse diameter > 2.8 cm/m2 in the 4-chamber view. In the study by Anderson et al , an absolute LA area < 24 cm2 and depth < 5.8 cm were the parameters that best distinguished normal from abnormal atria. With respect to LA volume estimators, we found that the best method included measurement of area in the 3 and 4-chamber views, transverse diameter in the 2 and 4-chamber views and the anteroposterior diameter. We correlated real volume with estimated volumes derived from this method and from the traditionally used biplane area-length and prolate ellipsoid methods. All of them correlated well but caused a significant underestimation of LA volume, with the worse accuracy found for the prolate ellipsoid method (mean difference of 50 ± 32 mL). Some studies have also compared methods of volume estimation with real volumes, with different results. Sievers et al  compared, in a group of 15 healthy subjects, the biplane area-length method with real volume, showing that the biplane area-length method caused a significant overestimation. An echocardiographic study by Badano et al  that sought to assess how many patients would be misclassified using M-mode or 2D estimates of LA size instead of real LA volume, showed that both 1D and 2D parameters were poor predictors of LA volume, especially in enlarged atria. Like the single plane area-length method, the prolate-ellipsoid method assumes an ellipsoid geometry for the LA but systematically calculates smaller volumes than the biplane methods, which stems from any error with the section of the 3 pairs of coordinates creating a large difference in the volume measurement. The biplane methods require planimetry from 2 orthogonal planes and any single error in tracing the endocardium is more forgiving because it is only 1 point among multiple points used for such tracing. Even the well-validated biplane methods have been shown to systematically underestimate LA volume when compared with MRI or CCT .
Atrial dimensions vary mainly by body surface area, with lesser effects of gender and age. Identification particularly of early abnormality requires reference ranges which normalize for all 3 variables. These ranges are supplied with this report in both tabular and graphical form and are of significant clinical and research utility for the interpretation of CMR studies. Also, best predictors of LA enlargement are provided.
List of abbreviations used
Cardiovascular magnetic resonance
Steady state free precession
Left ventricular outflow tract.
This research was supported by the National Institute for Health Research Cardiovascular Biomedical Research Unit of Royal Brompton Hospital and Imperial College. Support was also received from CORDA, the British Heart Foundation and Siemens.
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