Volume 15 Supplement 1
Coronary endothelial function is directly related to extent of weight loss in obese patients
© Hays et al; licensee BioMed Central Ltd. 2013
Published: 30 January 2013
Obesity is a risk factor for future cardiovascular events. Prior studies have shown that weight loss is related to improved peripheral vascular function. However, the relationship of weight loss to coronary endothelial function, which is impaired in early atherosclerosis and predicts future cardiovascular events, is not completely understood. By means of previously described non-invasive MRI methods combined with isometric handgrip to assess endothelial-dependent coronary vasoreactivity,4 we tested the hypothesis that weight loss over six months is associated with better coronary endothelial function (EndoFx) in obese, non-diabetic individuals.
Using 3T MRI combined with isometric handgrip exercise to quantify coronary endothelial-dependent vasoreactivity, we observed a significant relationship between the degree of weight change and coronary endothelial function as quantified by % CSA and % CBF change during handgrip stress. The present findings demonstrate that weight loss in obese and overweight subjects is correlated with better coronary EndoFx, independent of changes in triglyceride level. This MR approach permits the noninvasive study of EndoFx in obese patients and may offer important insights into the effects of long term therapeutic or lifestyle obesity interventions on coronary vascular function and atherosclerosis.
NIH/NHLBI (ROIHL084186, ARRA 3R01Hl084186-04S1) and American Heart Association.
- Manson JE: . N Engl J Med. 1995, 333: 677-685. 10.1056/NEJM199509143331101.View ArticlePubMedGoogle Scholar
- Mavri A: . Heart Vessels. 2011, 26: 31-38. 10.1007/s00380-010-0016-1.View ArticlePubMedGoogle Scholar
- Schachinger V: . Circulation. 2000, 101: 1899-1906. 10.1161/01.CIR.101.16.1899.View ArticlePubMedGoogle Scholar
- Hays AG: . J Am Coll Cardiol. 2010, 56: 1657-1665. 10.1016/j.jacc.2010.06.036.View ArticlePubMedGoogle Scholar
- Brown BG: . Circulation. 1984, 70: 18-24. 10.1161/01.CIR.70.1.18.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.