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Table 1 Cardiac Parameters for Male and Female WT and GAMT-ko Mice measured by MRI

From: Cardiac structure and function during ageing in energetically compromised Guanidinoacetate N-methyltransferase (GAMT)-knockout mice – a one year longitudinal MRI study

   6 weeks 4 months 8 months 12 months
   WT GAMT-ko WT GAMT-ko WT GAMT-ko WT GAMT-ko
n M
F
7
7
7
7
7
7
7
7
7
7
7
7
7
6
5
6
Body weight (g) M
F
22 ± 2
16 ± 1
17 ± 3
15 ± 1
29 ± 3
22 ± 1
24 ± 2
19 ± 1
32 ± 3
24 ± 2
24 ± 3
21 ± 3
35 ± 3
26 ± 3
25 ± 2
22 ± 2
LV Mass (mg) M
F
80 ± 6
71 ± 11
70 ± 13
67 ± 9
108 ± 12
94 ± 23
82 ± 11
86 ± 9
118 ± 9
91 ± 14
92 ± 11
86 ± 8
112 ± 19
101 ± 14
98 ± 8
90 ± 9
End-diastolic volume (μl) M
F
45 ± 6
49 ± 10
39 ± 12
44 ± 9
54 ± 8
55 ± 18
49 ± 18
47 ± 4
64 ± 13
58 ± 9
50 ± 16
52 ± 15
66 ± 12
63 ± 20
54 ± 15
57 ± 11
End-systolic volume (μl) M
F
16 ± 5
17 ± 5
11 ± 5
13 ± 4
23 ± 8
20 ± 9
16 ± 10
14 ± 1
24 ± 7
22 ± 4
21 ± 10
18 ± 7
28 ± 7
25 ± 12
19 ± 9
24 ± 7
Stroke volume (μl) M
F
29 ± 4
31 ± 6
28 ± 8
30 ± 6
31 ± 5
35 ± 10
32 ± 8
34 ± 4
40 ± 9
35 ± 8
29 ± 9
34 ± 10
38 ± 13
39 ± 9
35 ± 8
33 ± 5
Ejection fraction (%) M
F
65 ± 7
64 ± 4
72 ± 4
70 ± 7
58 ± 12
65 ± 4
68 ± 7
71 ± 4
62 ± 7
61 ± 6
58 ± 13
65 ± 8
56 ± 14
62 ± 6
66 ± 6
58 ± 6
Heart rate (bpm) M
F
485 ± 42
485 ± 25
506 ± 20
483 ± 46
555 ± 63
472 ± 27
465 ± 35
496 ± 45
514 ± 25
421 ± 24
450 ± 31
479 ± 43
488 ± 46
451 ± 51
441 ± 66
497 ± 14
Cardic output (ml · min-1) M
F
14.2 ± 1.4
15.2 ± 3.1
13.9 ± 3.3
14.4 ± 2.8
17.3 ± 3.3
16.6 ± 4.7
14.9 ± 3.4
14.6 ± 6.6
20.3 ± 4.0
14.8 ± 3.4
13.1 ± 4.5
16.0 ± 3.9
18.1 ± 6.0
17.3 ± 3.8
15.9 ± 5.5
16.1 ± 2.3
dV/dtmax.EDV-1
(103·s-1)
M
F
20.5 ± 5.0
24.7 ± 1.7
21.6 ± 3.5
23.2 ± 4.7
21.5 ± 5.0
22.1 ± 4.3
19.3 ± 1.7
23.3 ± 3.9
17.8 ± 3.2
19.9 ± 2.9
18.0 ± 2.1
21.3 ± 2.0
17.8 ± 3.7
18.7 ± 3.5
20.2 ± 4.1
20.5 ± 1.3
dV/dtmin.EDV-1
(103· s-1)
M
F
-18.2 ± 3.9
-15.0 ± 1.6
-21.3 ± 4.7
-18.6 ± 3.9
-17.8 ± 1.5
-16.7 ± 4.2
-21.7 ± 5.5
-20.8 ± 2.3
-19.4 ± 4.6
-15.0 ± 3.9
-16.7 ± 3.6
-17.3 ± 3.3
-15.8 ± 3.0
-16.8 ± 5.1
-17.5 ± 4.5
-15.8 ± 3.3
  1. All parameters are for the left ventricle(LV) and represent mean ± standard deviation.