Table 1 Cardiac Parameters for Male and Female WT and GAMT-ko Mice measured by MRI
6 weeks | 4 months | 8 months | 12 months | ||||||
|---|---|---|---|---|---|---|---|---|---|
WT | GAMT-ko | WT | GAMT-ko | WT | GAMT-ko | WT | GAMT-ko | ||
n | M F | 7 7 | 7 7 | 7 7 | 7 7 | 7 7 | 7 7 | 7 6 | 5 6 |
Body weight (g) | M F | 22 ± 2 16 ± 1 | 17 ± 3 15 ± 1 | 29 ± 3 22 ± 1 | 24 ± 2 19 ± 1 | 32 ± 3 24 ± 2 | 24 ± 3 21 ± 3 | 35 ± 3 26 ± 3 | 25 ± 2 22 ± 2 |
LV Mass (mg) | M F | 80 ± 6 71 ± 11 | 70 ± 13 67 ± 9 | 108 ± 12 94 ± 23 | 82 ± 11 86 ± 9 | 118 ± 9 91 ± 14 | 92 ± 11 86 ± 8 | 112 ± 19 101 ± 14 | 98 ± 8 90 ± 9 |
End-diastolic volume (μl) | M F | 45 ± 6 49 ± 10 | 39 ± 12 44 ± 9 | 54 ± 8 55 ± 18 | 49 ± 18 47 ± 4 | 64 ± 13 58 ± 9 | 50 ± 16 52 ± 15 | 66 ± 12 63 ± 20 | 54 ± 15 57 ± 11 |
End-systolic volume (μl) | M F | 16 ± 5 17 ± 5 | 11 ± 5 13 ± 4 | 23 ± 8 20 ± 9 | 16 ± 10 14 ± 1 | 24 ± 7 22 ± 4 | 21 ± 10 18 ± 7 | 28 ± 7 25 ± 12 | 19 ± 9 24 ± 7 |
Stroke volume (μl) | M F | 29 ± 4 31 ± 6 | 28 ± 8 30 ± 6 | 31 ± 5 35 ± 10 | 32 ± 8 34 ± 4 | 40 ± 9 35 ± 8 | 29 ± 9 34 ± 10 | 38 ± 13 39 ± 9 | 35 ± 8 33 ± 5 |
Ejection fraction (%) | M F | 65 ± 7 64 ± 4 | 72 ± 4 70 ± 7 | 58 ± 12 65 ± 4 | 68 ± 7 71 ± 4 | 62 ± 7 61 ± 6 | 58 ± 13 65 ± 8 | 56 ± 14 62 ± 6 | 66 ± 6 58 ± 6 |
Heart rate (bpm) | M F | 485 ± 42 485 ± 25 | 506 ± 20 483 ± 46 | 555 ± 63 472 ± 27 | 465 ± 35 496 ± 45 | 514 ± 25 421 ± 24 | 450 ± 31 479 ± 43 | 488 ± 46 451 ± 51 | 441 ± 66 497 ± 14 |
Cardic output (ml · min-1) | M F | 14.2 ± 1.4 15.2 ± 3.1 | 13.9 ± 3.3 14.4 ± 2.8 | 17.3 ± 3.3 16.6 ± 4.7 | 14.9 ± 3.4 14.6 ± 6.6 | 20.3 ± 4.0 14.8 ± 3.4 | 13.1 ± 4.5 16.0 ± 3.9 | 18.1 ± 6.0 17.3 ± 3.8 | 15.9 ± 5.5 16.1 ± 2.3 |
dV/dtmax.EDV-1 (103·s-1) | M F | 20.5 ± 5.0 24.7 ± 1.7 | 21.6 ± 3.5 23.2 ± 4.7 | 21.5 ± 5.0 22.1 ± 4.3 | 19.3 ± 1.7 23.3 ± 3.9 | 17.8 ± 3.2 19.9 ± 2.9 | 18.0 ± 2.1 21.3 ± 2.0 | 17.8 ± 3.7 18.7 ± 3.5 | 20.2 ± 4.1 20.5 ± 1.3 |
dV/dtmin.EDV-1 (103· s-1) | M F | -18.2 ± 3.9 -15.0 ± 1.6 | -21.3 ± 4.7 -18.6 ± 3.9 | -17.8 ± 1.5 -16.7 ± 4.2 | -21.7 ± 5.5 -20.8 ± 2.3 | -19.4 ± 4.6 -15.0 ± 3.9 | -16.7 ± 3.6 -17.3 ± 3.3 | -15.8 ± 3.0 -16.8 ± 5.1 | -17.5 ± 4.5 -15.8 ± 3.3 |