Table 1 Cardiac Parameters for Male and Female WT and GAMT-ko Mice measured by MRI
| 6 weeks | 4 months | 8 months | 12 months | ||||||
|---|---|---|---|---|---|---|---|---|---|
| WT | GAMT-ko | WT | GAMT-ko | WT | GAMT-ko | WT | GAMT-ko | ||
| n |
M F |
7 7 |
7 7 |
7 7 |
7 7 |
7 7 |
7 7 |
7 6 |
5 6 |
| Body weight (g) |
M F |
22 ± 2 16 ± 1 |
17 ± 3 15 ± 1 |
29 ± 3 22 ± 1 |
24 ± 2 19 ± 1 |
32 ± 3 24 ± 2 |
24 ± 3 21 ± 3 |
35 ± 3 26 ± 3 |
25 ± 2 22 ± 2 |
| LV Mass (mg) |
M F |
80 ± 6 71 ± 11 |
70 ± 13 67 ± 9 |
108 ± 12 94 ± 23 |
82 ± 11 86 ± 9 |
118 ± 9 91 ± 14 |
92 ± 11 86 ± 8 |
112 ± 19 101 ± 14 |
98 ± 8 90 ± 9 |
| End-diastolic volume (μl) |
M F |
45 ± 6 49 ± 10 |
39 ± 12 44 ± 9 |
54 ± 8 55 ± 18 |
49 ± 18 47 ± 4 |
64 ± 13 58 ± 9 |
50 ± 16 52 ± 15 |
66 ± 12 63 ± 20 |
54 ± 15 57 ± 11 |
| End-systolic volume (μl) |
M F |
16 ± 5 17 ± 5 |
11 ± 5 13 ± 4 |
23 ± 8 20 ± 9 |
16 ± 10 14 ± 1 |
24 ± 7 22 ± 4 |
21 ± 10 18 ± 7 |
28 ± 7 25 ± 12 |
19 ± 9 24 ± 7 |
| Stroke volume (μl) |
M F |
29 ± 4 31 ± 6 |
28 ± 8 30 ± 6 |
31 ± 5 35 ± 10 |
32 ± 8 34 ± 4 |
40 ± 9 35 ± 8 |
29 ± 9 34 ± 10 |
38 ± 13 39 ± 9 |
35 ± 8 33 ± 5 |
| Ejection fraction (%) |
M F |
65 ± 7 64 ± 4 |
72 ± 4 70 ± 7 |
58 ± 12 65 ± 4 |
68 ± 7 71 ± 4 |
62 ± 7 61 ± 6 |
58 ± 13 65 ± 8 |
56 ± 14 62 ± 6 |
66 ± 6 58 ± 6 |
| Heart rate (bpm) |
M F |
485 ± 42 485 ± 25 |
506 ± 20 483 ± 46 |
555 ± 63 472 ± 27 |
465 ± 35 496 ± 45 |
514 ± 25 421 ± 24 |
450 ± 31 479 ± 43 |
488 ± 46 451 ± 51 |
441 ± 66 497 ± 14 |
| Cardic output (ml · min-1) |
M F |
14.2 ± 1.4 15.2 ± 3.1 |
13.9 ± 3.3 14.4 ± 2.8 |
17.3 ± 3.3 16.6 ± 4.7 |
14.9 ± 3.4 14.6 ± 6.6 |
20.3 ± 4.0 14.8 ± 3.4 |
13.1 ± 4.5 16.0 ± 3.9 |
18.1 ± 6.0 17.3 ± 3.8 |
15.9 ± 5.5 16.1 ± 2.3 |
|
dV/dtmax.EDV-1 (103·s-1) |
M F |
20.5 ± 5.0 24.7 ± 1.7 |
21.6 ± 3.5 23.2 ± 4.7 |
21.5 ± 5.0 22.1 ± 4.3 |
19.3 ± 1.7 23.3 ± 3.9 |
17.8 ± 3.2 19.9 ± 2.9 |
18.0 ± 2.1 21.3 ± 2.0 |
17.8 ± 3.7 18.7 ± 3.5 |
20.2 ± 4.1 20.5 ± 1.3 |
|
dV/dtmin.EDV-1 (103· s-1) |
M F |
-18.2 ± 3.9 -15.0 ± 1.6 |
-21.3 ± 4.7 -18.6 ± 3.9 |
-17.8 ± 1.5 -16.7 ± 4.2 |
-21.7 ± 5.5 -20.8 ± 2.3 |
-19.4 ± 4.6 -15.0 ± 3.9 |
-16.7 ± 3.6 -17.3 ± 3.3 |
-15.8 ± 3.0 -16.8 ± 5.1 |
-17.5 ± 4.5 -15.8 ± 3.3 |