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Table 2 Summary of the significant findings from the mixed-effects regression

From: Cardiac structure and function during ageing in energetically compromised Guanidinoacetate N-methyltransferase (GAMT)-knockout mice – a one year longitudinal MRI study

Trait a Factor b Coefficient estimate 95% CI P-value
BW Sex -5.13 [-6.72, -3.54] <0.0001
  Genotype -2.40 [-4.3, -0.49] <0.0001
  Time - - <0.0001
     4 months 6.34 [4.86, 7.82] <0.0001
     8 months 8.28 [6.9, 9.66] <0.0001
     12 months 11.73 [10.33, 13.13] <0.0001
  Genotype*Time - - 0.0003
     Genotype*4 months -1.52 [-3.55, 0.52] 0.1415
     Genotype*8 months -2.60 [-4.56, -0.64] 0.0102
     Genotype*12 months -4.79 [-6.88, -2.69] <0.0001
LVM BW 0.88 [-0.06, 1.81] <0.0001
  Sex -4.50 [-13.36, 4.35] 0.2636
  Genotype -8.85 [-16.91, -0.78] 0.7443
  Time - - 0.0003
     4 months 15.35 [7.9, 22.8] 0.0001
     8 months 18.55 [10.27, 26.84] <0.0001
     12 months 19.29 [8.84, 29.74] 0.0005
EF Sex 1.06 [-2.55, 4.66] 0.4924
  Genotype 3.46 [-0.02, 6.94] 0.0334
  Time - - 0.0027
     4 months -1.43 [-5.58, 2.72] 0.4947
     8 months -5.42 [-9.44, -1.4] 0.009
     12 months -7.30 [-11.55, -3.06] 0.001
Heart rate Sex -48.49 [-74.64, -22.33] 0.1958
  Genotype -42.08 [-67.96, -16.2] 0.698
  Time - - 0.0519
     4 months 4.99 [-17.61, 27.58] 0.6611
     8 months -23.16 [-44.79, -1.54] 0.0362
     12 months -20.67 [-43.49, 2.15] 0.0751
  Sex*Genotype 73.26 [35.93, 110.6] 0.0004
dV/dtmax.EDV-1 Sex 0.002 [0.001, 0.004] 0.0048
  Genotype 0.000 [-0.001, 0.002] 0.8454
  Time    0.0009
     4 months -0.001 [-0.003, 0.001] 0.2688
     8 months -0.003 [-0.005, -0.001] 0.0017
     12 months -0.004 [-0.005, -0.002] 0.0004
  1. a Traits for which at least one factor in the model had significant (P < 0.01) effects.
  2. b Estimated effects of KO compared to WT (baseline) for Genotype, female compared to male (baseline) for Sex, and trait values at 4 months, 8 months, and 12 months compared to trait values at 6 weeks (baseline) for Time (3df test)