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241 Cardiac T2* MRI at 3.0 Tesla for the detection of myocardial ischemia
Journal of Cardiovascular Magnetic Resonance volume 10, Article number: A102 (2008)
Alterations of myocardial oxygenation/microcirculation can be studied by measurements of the transverse relaxation time T2*, which represents a measure for the oxygenation level of hemoglobin.
Purpose of this study was to evaluate the diagnostic performance of cardiac T2* measurements during adenosine stress for the detection of myocardial ischemia.
16 patients (mean age 63 ± 9 years, 6 female) suspected of having coronary artery disease and being scheduled for invasive coronary angiography underwent cardiac MR (CMR) imaging at 3.0 T (Philips Achieva, Best, NL). T2* measurements were performed in 3 short axis slices of the heart (6 echoes per slice) at rest and under adenosine stress (140 μg/kg/min over 6 min).
Quantitative coronary angiography served as standard of reference (significant luminal diameter narrowing ≥ 50%). Average T2* values of the myocardium were calculated from the mean value of the signal intensities in the ROI using the standard 16 segment model.
7 patients (44%) had significant coronary disease; T2* measurement resulted in a sensitivity and specificity of 86% and 67%, respectively (patient based analysis; area-under-curve from ROC-analysis: 0.65).
Cardiac T2* measurements under adenosine stress at 3 T can detect myocardial ischemia in the presence of coronary artery stenosis.
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Manka, R., Jahnke, C., Schnackenburg, B. et al. 241 Cardiac T2* MRI at 3.0 Tesla for the detection of myocardial ischemia. J Cardiovasc Magn Reson 10, A102 (2008). https://doi.org/10.1186/1532-429X-10-S1-A102
- Coronary Artery Disease
- Coronary Artery
- Myocardial Ischemia
- Coronary Angiography