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241 Cardiac T2* MRI at 3.0 Tesla for the detection of myocardial ischemia

Introduction

Alterations of myocardial oxygenation/microcirculation can be studied by measurements of the transverse relaxation time T2*, which represents a measure for the oxygenation level of hemoglobin.

Purpose

Purpose of this study was to evaluate the diagnostic performance of cardiac T2* measurements during adenosine stress for the detection of myocardial ischemia.

Methods

16 patients (mean age 63 ± 9 years, 6 female) suspected of having coronary artery disease and being scheduled for invasive coronary angiography underwent cardiac MR (CMR) imaging at 3.0 T (Philips Achieva, Best, NL). T2* measurements were performed in 3 short axis slices of the heart (6 echoes per slice) at rest and under adenosine stress (140 μg/kg/min over 6 min).

Quantitative coronary angiography served as standard of reference (significant luminal diameter narrowing ≥ 50%). Average T2* values of the myocardium were calculated from the mean value of the signal intensities in the ROI using the standard 16 segment model.

Results

7 patients (44%) had significant coronary disease; T2* measurement resulted in a sensitivity and specificity of 86% and 67%, respectively (patient based analysis; area-under-curve from ROC-analysis: 0.65).

Conclusion

Cardiac T2* measurements under adenosine stress at 3 T can detect myocardial ischemia in the presence of coronary artery stenosis.

Author information

Correspondence to Robert Manka.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Manka, R., Jahnke, C., Schnackenburg, B. et al. 241 Cardiac T2* MRI at 3.0 Tesla for the detection of myocardial ischemia. J Cardiovasc Magn Reson 10, A102 (2008). https://doi.org/10.1186/1532-429X-10-S1-A102

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Keywords

  • Coronary Artery Disease
  • Coronary Artery
  • Luminal
  • Myocardial Ischemia
  • Coronary Angiography