Skip to main content

2007 Blood oxygen level-dependent MRI in myocardium and skeletal muscle at 1.5 T and 3.0 T

Background

Blood-oxygen level dependent (BOLD) cardiac magnetic resonance imaging (CMR) is a potential diagnostic tool to differentiate ischemic from non-ischemic myocardium.

Methods

T2* values of the myocardial and calf muscle were measured and compared between 1.5 T and 3 T to quantify the respective changes in the tissue T2* property, its dependency on the spatial resolution and to assess the sensitivity of the different field strength for hypoxia. T2* mapping of the calf muscle was performed in 15 volunteers before, during and after no-flow ischemia of the leg. In 23 healthy volunteers T2* maps of the myocardium were generated. Additionally, T2* was measured during adenosine infusion in eight volunteers.

Results

Mean myocardial T2* at 1.5 T was 47.96 ± 10.69 ms and at 3 T 20.44 ± 4.49 ms. After obstruction of the leg the T2* reduction of the calf at 1.5 T was 3.4% (p = 0.001) and 13.0% at 3 T (p < 0.0001). T2* relaxation increased significantly during adenosine at 1.5 T and 3 T (p < 0.0001).

Conclusion

T2* quantification at 1.5 T and 3 T yields a linear relationship. No significant difference could be observed between breath hold and respiratory navigator gated techniques indicating the feasibility of T2* quantification at high spatial resolution. The T2* decrease during hypoxemia of the calf ant the increase during hyperemia of the myocardium indicate that our presented protocol could possibly be applied for evaluation of inducible myocardial ischemia.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Peter Bernhardt.

Rights and permissions

Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and Permissions

About this article

Cite this article

Bernhardt, P., Bornstedt, A., Spiess, J. et al. 2007 Blood oxygen level-dependent MRI in myocardium and skeletal muscle at 1.5 T and 3.0 T. J Cardiovasc Magn Reson 10, A276 (2008). https://doi.org/10.1186/1532-429X-10-S1-A276

Download citation

Keywords

  • Magnetic Resonance Imaging
  • Ischemia
  • Skeletal Muscle
  • Adenosine
  • Field Strength