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127 Coronary Wall MRI detects subclinical atherosclerosis in asymptomatic individuals in the multi-ethnic study of atherosclerosis (MESA)
© Macedo et al; licensee BioMed Central Ltd. 2008
- Published: 22 October 2008
- Cardiovascular Risk Factor
- Atherosclerotic Disease
- Asymptomatic Individual
- Subclinical Atherosclerosis
Coronary wall MRI has been shown to demonstrate increased thickness of the coronary wall in individuals with documented coronary artery disease.
The purpose of this study was to evaluate the usefulness of coronary wall MRI as a measure of atherosclerotic disease burden in an asymptomatic population free of clinical cardiovascular disease.
Forty eight consecutive subjects in the Multi-Ethnic Study of Atherosclerosis (MESA) study underwent coronary wall MRI of the left and right coronary arteries at 5 mm intervals using a black blood turbo spin echo technique.
Maximum coronary wall thickness was greater for subjects with 2 or more cardiovascular risk factors than for those with 1 or no risk factors (2.59 ± 0.33 mm versus 2.36 ± 0.30 mm, respectively, p = 0.05.) For subjects with zero coronary calcium score, the mean and maximum coronary wall thickness for subjects with 2 or more risk factors for coronary artery disease were greater than the wall thickness for subjects with 1 or no risk factors (mean thickness: 1.95 ± 0.17 mm versus 1.7 ± 0.19 mm; maximum thickness: 2.67 ± 0.24 mm versus 2.32 ± 0.27 mm, respectively, p < 0.05). Subjects with carotid intimal-medial thickness (IMT) greater than one standard deviation (SD) above the mean had significantly higher mean and maximum coronary wall thickness compared to subjects with carotid IMT less than or equal to one SD above the mean (p < 0.05).
This article is published under license to BioMed Central Ltd.