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127 Coronary Wall MRI detects subclinical atherosclerosis in asymptomatic individuals in the multi-ethnic study of atherosclerosis (MESA)
Journal of Cardiovascular Magnetic Resonance volume 10, Article number: A28 (2008)
Introduction
Coronary wall MRI has been shown to demonstrate increased thickness of the coronary wall in individuals with documented coronary artery disease.
Purpose
The purpose of this study was to evaluate the usefulness of coronary wall MRI as a measure of atherosclerotic disease burden in an asymptomatic population free of clinical cardiovascular disease.
Methods
Forty eight consecutive subjects in the Multi-Ethnic Study of Atherosclerosis (MESA) study underwent coronary wall MRI of the left and right coronary arteries at 5 mm intervals using a black blood turbo spin echo technique.
Results
Maximum coronary wall thickness was greater for subjects with 2 or more cardiovascular risk factors than for those with 1 or no risk factors (2.59 ± 0.33 mm versus 2.36 ± 0.30 mm, respectively, p = 0.05.) For subjects with zero coronary calcium score, the mean and maximum coronary wall thickness for subjects with 2 or more risk factors for coronary artery disease were greater than the wall thickness for subjects with 1 or no risk factors (mean thickness: 1.95 ± 0.17 mm versus 1.7 ± 0.19 mm; maximum thickness: 2.67 ± 0.24 mm versus 2.32 ± 0.27 mm, respectively, p < 0.05). Subjects with carotid intimal-medial thickness (IMT) greater than one standard deviation (SD) above the mean had significantly higher mean and maximum coronary wall thickness compared to subjects with carotid IMT less than or equal to one SD above the mean (p < 0.05).
Conclusion
MRI detects increased coronary wall thickness in asymptomatic individuals with subclinical markers of atherosclerotic disease and in individuals with zero coronary calcium score.
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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Macedo, R., Chen, S., Lai, S. et al. 127 Coronary Wall MRI detects subclinical atherosclerosis in asymptomatic individuals in the multi-ethnic study of atherosclerosis (MESA). J Cardiovasc Magn Reson 10 (Suppl 1), A28 (2008). https://doi.org/10.1186/1532-429X-10-S1-A28
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DOI: https://doi.org/10.1186/1532-429X-10-S1-A28