- Meeting abstract
- Open Access
2036 Acute alcohol-induced myocardial inflammation as visualized by cardiac magnetic resonance
© Zagrosek et al; licensee BioMed Central Ltd. 2008
- Published: 22 October 2008
- Contrast Agent
- Ventricular Function
- Alcohol Intake
- Cardiac Magnetic Resonance
- Myocardial Inflammation
Intoxication with large amounts of ethanol is known to induce a systemic, inflammatory reaction including excretion of several cytokines, most often leading to the so-called "hangover". We hypothesised that the systemic inflammatory imbalance leads to a transient sterile myocardial inflammation which can be visualized by cardiac magnetic resonance (CMR) employing the techniques established for the diagnosis of inflammatory myocardial injury.
In 10 healthy volunteers (age mean ± SD 31.6 ± 2.8 yrs., BMI 22.6 ± 2.0, 3 female) a hangover was induced experimentally by consumption of large amounts of vodka. After 1 week of abstinence from alcohol, participants were examined in a 1.5 T CMR-System before, 12 h and 1 week after alcohol intake. The CMR protocol included cine-imaging for cardiac function and volumes, T2-weighted techniques for detection of cardiac edema (T2-ratio: ratio of signal intensitiy of myocardium/sceletal muscle), "early" global relative enhancement (gRE, axial spin-echo sequence comparing myocardial and sceletal uptake of contrast agent) and late hyperenhancement for detection of myocardial scarring. Blood alcohol level (BAL) was assessed 45 min. after termination of alcohol intake. The study was approved by the local ethics committee.
All participants suffered from a clinical "hangover" 12 h after alcohol intake (headache, nausea, fatigue, tremulousness, tachycardia). The mean BAL at "top-of-drinking" was 1.1 ± 0.3‰ (1.4 ± 0.4 g/l). In CMR, a significant increase in signal intensity on T2-weighted images was observed on the day after drinking (T2-ratio 1.7 ± 0.2 vs. 1.9 ± 0.2, p = 0.04). In 8 participants (80%) gRE after drinking was significantly enhanced as well (3.9 ± 1.3 vs. 6.8 ± 3.1, p = 0.03). The CMR-parameters returned to baseline values within 1 week after alcohol intake in 9 participants (90%). Left ventricular function and volumes remained unchanged during all three CMR exams. On late hyperenhancement images, no areas of focal necrosis were detectable.
This study supports the hypothesis that even moderate alcohol-intoxication leads to a transient myocarditis-like inflammation of the myocardium which is detectable by CMR. Larger studies are required to verify the present findings.
This article is published under license to BioMed Central Ltd.