Left ventricular T2 distribution in Duchenne Muscular Dystrophy
© Wansapura et al; licensee BioMed Central Ltd. 2009
Published: 28 January 2009
The transverse relaxation time (T2) of water molecules differ between tissues. Because the molecular motion of water is significantly affected by macro molecules, tissue containing fibrous polymers such as collagen has shorter T2 values. Patients with Duchenne Muscular Dystrophy (DMD) develop myocardial fibrosis in the late stage of the disease. The goal of this study was to determine the association of myocardial T2 distribution to the severity of DMD.
Twenty six DMD patients and eight normal subjects were studied. T2 maps of the left ventricle were generated using a black blood dual spin echo method. (TE1 = 6 ms, TE2 = 34 ms) DMD patients were grouped according to the ejection fraction (EF) and the circumferential strain (εcc) as: A: EF ≥ 56%, εcc ≥ 12%, mean age = 10.5 yrs, B: EF ≥ 56%, εcc ≤ 12%, mean age = 17.5 yrs, C: EF ≤ 56%, mean age = 17.5 yrs. T2 values were plotted for each subject as a histogram. The normalized mean histograms from each group were compared by the Full Width of Half Maximum (FWHM).
The FWHM of the T2 histogram was significantly higher in group B and C compared to that of group A and the normal group, indicating significantly high heterogeneity in T2 in Group B and C. FWHM/T2mean is significantly (p < .0001) higher in group B (0.42 ± 0.06) compared to Group A (0.54 ± 0.08). Regression analysis show moderate association between FWHM/T2mean and |Ecc| in group A and B. (Pearson correlation coefficient r = .51).
This article is published under license to BioMed Central Ltd.