Poster presentation | Open | Published:
Cardio-metabolic profile is a determinant of carotid artery disease quantified by Magnetic Resonance Imaging
Journal of Cardiovascular Magnetic Resonancevolume 11, Article number: P166 (2009)
Magnetic Resonance Imaging (MRI) can be used to measure common carotid artery wall volume (CCA-CWV) and maximum wall thickness (CCA-CWT) that incorporates adventitial thickness in addition to intima-media thickness (CCA-IMT). Although, the predictors of CCA-IMT are well known, those of CCA-CWV and CCA-CWT have not been studied.
We hypothesized that patients with higher CCA-CWV and CCA-CWT have lower high-density lipoprotein (HDL) levels and greater incidence of metabolic syndrome.
One hundred and three subjects with IMT >0.65 mm underwent MRI of their carotid arteries using T2-weighted black-blood sequence transaxial slices to measure CCA-CWV and CCA-CWT. Blood pressure (BP), body mass index (BMI), fasting lipid profile and glucose were measured. Metabolic syndrome (MetS) was defined in patients as having ≥ 3 risk factors, BMI ≥ 30, TG ≥ 150 mg/dl, HDL ≤ 40 mg/dl in men and ≤50 mg/dl in women, BP ≥ 130/85 and fasting glucose ≥ 110 mg/dl.
CCA-CWV correlated negatively with serum HDL levels (r = -0.373, p < 0.0001), positively with BMI (r = 0.54, p < 0.0001) and diastolic BP (r = 0.28, p = 0.009) independent of age, sex, the presence of diabetes, hypertension, hyperlipidemia and smoking. CCA-CWT correlated negatively with serum HDL levels (and r = -0.255, p = 0.01) and positively with presence of MetS (r = 0.23, p = 0.02) independent of age, gender and history of smoking.
Cardio-metabolic profile is a predictor of carotid artery disease as quantified by magnetic resonance imaging.