Skip to content


Journal of Cardiovascular Magnetic Resonance

Open Access

The association of C-reactive protein with left ventricular systolic function and left ventricular myocardial fibrosis

  • Mohammed Ahmed1,
  • Ijaz Ahmad1,
  • Munawar Hayat1,
  • Jasmin Ullah1,
  • Nadeem Asad1,
  • Joshua A Socolow1,
  • Igor Klem2,
  • Matt Briggs1,
  • Terrence Sacchi1 and
  • John F Heitner1
Journal of Cardiovascular Magnetic Resonance200911(Suppl 1):P45

Published: 28 January 2009


Congestive Heart FailureLeave Ventricular Ejection FractionPeripheral Vascular DiseaseMyocardial FibrosisIschemic Cardiomyopathy


C-reactive Protein (CRP) is a serologic marker that has been shown to predict adverse cardiovascular outcomes. In addition, CRP has been shown to be elevated in patients with congestive heart failure (CHF).


To evaluate if CRP is associated with the severity of left ventricular dysfunction, independent of the degree of myocardial fibrosis.


We prospectively evaluated 46 outpatients referred to our cardiac MRI (CMR) center for the evaluation of ischemic cardiomyopathy (LVEF < 45%). Patients were excluded if they were discharged from the hospital within 7 days of the CMR study or were in acute CHF by clinical exam on the day of the study. Blood samples were drawn for the measurement of CRP on the day of the CMR. All patients had left ventricular function and amount of scar tissue calculated by computer analysis after ROI curves were performed.


The average age of the patients was 67.7 years (36 males and 10 females). The prevalence of the following risk factors was as follows: hyperlipidemia (80%), hypertension (77%), diabetes (50%), tobacco (14%), renal disease (11%), and peripheral vascular disease (7%). The mean left ventricular ejection fraction (LVEF) was 36.7%. The mean left ventricular myocardial fibrosis was 16 g. Separate regression models were applied for CRP predicting left ventricular myocardial fibrosis and LVEF. The log CRP was associated with both left ventricular myocardial fibrosis (p = 0.05) and LVEF (p = 0.03). In addition, the log CRP was associated with a low ejection fraction, independent of the amount of left ventricular myocardial fibrosis (p = 0.03).


CRP is an independent predictor of left ventricular ejection fraction in patients with ischemic cardiomyopathy.

Authors’ Affiliations

New York Methodist Hospital, Brooklyn, USA
Duke University Medical Center, Durham, USA


© Ahmed et al; licensee BioMed Central Ltd. 2009

This article is published under license to BioMed Central Ltd.