Figure 3

Differentiation between Acute vs. Subacute Myocardial Infarctions. A: TTC stained photograph of a canine (Dog#1) transversal LV slice 32 days following the first (LAD) and 4 days after second (LCx) infarct. White arrows point to the acute infarct located in the posterior and postero-lateral segments (LCx-supply area). Subacute infarct (white arrowheads) is seen on the border of the anteroseptal and anterior segment (LAD-supply area). B: Corresponding LE CMR image taken in the presence of Gd(DTPA). This CA does not differentiate between the acute and the subacute infarcts. C: Same as B, after the endo- and epicardial contours of the LV muscle had been traced manually D: Image in C thresholded at normal+6SD intensity. E: Same CMR image as in B, taken in the presence of Gd(ABE-DTTA) one day following B. Only the posterior and postero-lateral segments, i.e. the acute infarct, show LE. The subacute infarct is not highlighted by this agent, thereby differentiating between acute and subacute infarcts. F: Same as E, after the endo- and epicardial contours of the LV muscle had been traced manually. G: Image F thresholded at normal+6SD intensity. H: TTC photograph of another canine (Dog#2) LV slice 32 days following first (LAD) and 4 days after second (LCx) infarct. White arrows point to the acute (hemorrhagic) infarct in the posteromedial papillary muscle (LCx-supply area). Subacute infarct (white arrowheads) is seen predominantly in the anterolateral papillary muscle (LAD-supply area). I: Corresponding LE image with Gd(DTPA). J: Same as I, after the contours of the LV muscle had been traced K: Image J thresholded at normal+6SD L: Same CMR image as in I, taken in the presence of Gd(ABE-DTTA) one day following I. Only the acute infarct shows LE. The subacute infarct is not highlighted by this agent. M: Same as L, after the contours had been traced N: Image M thresholded at normal+6SD.