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  • Oral presentation
  • Open Access

Quantitative assessment of late gadolinium-enhancement in cardiac magnetic resonance predicts left ventricular remodeling in acute myocarditis

  • 1,
  • 1,
  • 1,
  • 2 and
  • 1
Journal of Cardiovascular Magnetic Resonance201012 (Suppl 1) :O53

https://doi.org/10.1186/1532-429X-12-S1-O53

  • Published:

Keywords

  • Ejection Fraction
  • Acute Phase
  • Left Ventricular Ejection Fraction
  • Cardiac Magnetic Resonance
  • Myocarditis

Purpose

Cardiac magnetic resonance (CMR) is a major tool for the diagnosis of acute myocarditis. CMR allows myocardial inflammation visualization, especially with the T2 weighted and the late gadolinium enhancement (LGE) sequences. The aim of our study was to assess the value of LGE quantification to predict left ventricular (LV) remodeling.

Methods and results

We screened 33 consecutive patients hospitalized with the clinical diagnosis of acute myocarditis. CMR with delayed-enhancement sequences was performed during the acute phase and at 3 months for 21 patients. LGE mass (in the acute phase) was measured and compared to left ventricular ejection fraction (EF), LV mass, LV end-diastolic volume and LV end-systolic volume, in the acute episode and at 3 months.

During the acute phase, LGE was present in 18 patients (90.5%). LGE mass significantly decrease at 3 months. EF significantly improves between the acute phase and 3 months later (52 ± 11.7% vs. 59.5 ± 9.1%, p < 0.01). There was an inverse correlation between LGE mass in the acute phase and EF at 3 months (r = - 0.44, p = 0.044). The LGE mass in the acute phase was correlated with LV EDV (r = 0.62, p = 0.003) and LV ESV at 3 months (r = 0.76, p < 0.001). LGE mass decrease was significantly correlated with the improvement of EF between the acute phase and 3 months (r = - 0.82, p < 0.001).

Conclusion

LGE quantification in the acute phase of myocarditis may predict LV remodeling.

Authors’ Affiliations

(1)
Centre Hospitalo-universitaire, service de cardiologie, ANGERS, France
(2)
Centre Hospitalo-universitaire, service de radiologie, ANGERS, France

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