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Prevalence of late gadolinium enhancement in magnetic resonance imaging of patients with left ventricular non-compaction cardiomyopathy
© Wilhelm et al; licensee BioMed Central Ltd. 2010
Published: 21 January 2010
Left ventricular non-compaction cardiomyopathy (LVNC) is a comparatively rare finding which has similar morphological features in cadiac magnetic resonance imaging (cMRI) as those found in other myocardial disorders.
The purpose of our study was to define additional morphological criteria to the already known non-compaction/compaction ratio described by Jenni et al..
14 patients (11 male, average age 37 years) with positive Jenni-criterion for LVNC in echocardiography underwent cMRI (Siemens Sonata 1.5 T). Cine TruFISP, TSE T1- (pre and post contrast Early Gadolinium Enhancement ratio (EGEr) according to Friedrich et al. 1998) and T2-wheighted images (Edema Ratio (ER - myocardial signal intensity (SI)/scelettal muscle (SI)) were acquired as well as additional late gadolinium enhancement images (LGE) after administration of 0.2 mmol gadodiamide per kg body weight. LGE was deemed as either beeing present or not.
Mean EF 45% (± 18), EDV 174 (± 88)ml and ESV 107 (± 95)ml, Early Gadolinium Enhancement ratio and Edema Ratio had no pathological results in none of the patients (T1 = EGEr 3,2 ± 1.6, T2 = ER 1.6 ± 0.7). 6 patients had LGE and 8 patients had a limited left ventricular ejection fraction. In patients with heart failure 50% showed LGE, in patients with regular LV-function 30% showed LGE. LGE had a subendocardial cougar like pattern. 3 patients showed a circuript non-compacted myocardium, 3 patients achieved Jenni-criterion in only one axis-view (long axis or short axis) despite having severly limited ejection fraction, of those 2 had the typical LGE. In 11 patients the whole apex or more than half of left LV-cavity-circumference was concerned. In one case a biventricular affection was found.
CMR is well applicable for detection of LVNC. LGE might be an additional criterion for diagnosing LVNC in patients with circuript positive Jenni criterion, it seems to define a subgroup with more severely limited LV-EF.
This article is published under license to BioMed Central Ltd.