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Table 2 Size and parameters of systolic and diastolic function and CMR in hearts of patients with multiple transfusion vs Controls

From: Iron overload in polytransfused patients without heart failure is associated with subclinical alterations of systolic left ventricular function using cardiovascular magnetic resonance tagging

  

patients

  
  

T2* ≤ 10 ms

(n = 5)

T2* 11-20 ms

(n = 5)

T2* > 20

(n = 9)

Controls (n = 8)

P value ANOVA

 

LV mass (g/m2)

78 ± 21

65 ± 12

76 ± 17

68 ± 9

.21 (NS)

 

Apex-Base lenght (mm)

63 ± 5¶

67 ± 5¶

60 ± 10¶

81 ± 6

<.001

 

LV diameter base (mm)

41 ± 3

42 ± 5

48 ± 7

50 ± 6

.02

LV Size

LV EDVi (ml/m2)

95 ± 16

81 ± 18

83 ± 14

84 ± 7

.63 NS)

 

LV ESVi (ml/m2)

44 ± 9

35 ± 13

32 ± 9

29 ± 6

.11 (NS)

 

LA area (ml/m2)

46 ± 11

39 ± 12

35 ± 10

43 ± 16

.42 (NS)

 

LV EF (%)

54 ± 3¶

59 ± 7

62 ± 6

65 ± 6

.01

 

Ejection time (ms)

267 ± 20

280 ± 27

263 ± 35¶

306 ± 13

.06 (NS)

 

LV Rotation apex (°)

7 ± 2¶

9 ± 4¶

11 ± 5¶

19 ± 6

<.001

Systolic parameters

LV Rotation base (°)

-2 ± 1

-3 ± 2

-4 ± 3

-3 ± 2

.44 (NS)

 

LV Torsion uncorrected(°)

10 ± 2¶

12 ± 4¶

15 ± 6¶

23 ± 5

<.001

 

LV Twist φ corrected for LV length and radius (°)

1.6 ± 0.2¶†

1.9 ± 0.5¶

3.0 ± 1.2

3.5 ± 0.7

.002

 

End-systolic Ecc (%)

-10 ± 3

-14 ± 3

-12 ± 4

-16 ± 3

.05

 

End-systolic Err (%)

+6 ± 4¶

+9 ± 2

+11 ± 1

+11 ± 4

.05

 

Peak systolic twist rate

(°/msec)

7 ± 2

9 ± 3

12 ± 5

13 ± 4

.07 (NS)

 

PFR (ms)

581 ± 188

504 ± 232

643 ± 191

700 ± 134

.27 (NS)

 

E wave amplitude (cm/s)

77 ± 3

78 ± 12

69 ± 9

64 ± 10

.08 (NS)

 

A wave amplitude (cm/s)

29 ± 3

34 ± 12

36 ± 6

37 ± 12

.66 (NS)

Diastolic parameters

E/A ratio

2.7 ± 0.2

2.6 ± 1.1

2.0 ± 0.4

2.2 ± 0.8

.61 (NS)

 

DT (ms)

131 ± 16

116 ± 20

128 ± 29

154 ± 31

.21(NS)

 

E' wave amplitude septum (cm/s)

13 ± 8

10 ± 3

11 ± 5

11 ± 3

.91 (NS)

 

E' wave amplitude

lateral wall (cm/s)

19 ± 7

13 ± 5

17 ± 5

15 ± 2

.67 (NS)

 

E/e' septum

8 ± 5

8 ± 3

7 ± 2

6 ± 2

.50 (NS)

 

E/e' lateral

4 ± 1

7 ± 4

4 ± 2

4 ± 1

.25 (NS)

 

IVRT (ms)

50 ± 4

71 ± 19

65 ± 10

73 ± 20

.48 (NS)

 

Peak diastolic untwist rate (°/msec)

-7 ± 2

-9 ± 2

-18 ± 11

-17 ± 10

.10 (NS)

  1. LV: Left ventricular, EDVi: indexed End-diastolic volume, ESVi indexed End-systolic volume, LA: Left atrial, EF: Ejection fraction, Ecc: Eulerian circumferential shortening, Err: Eulerian radial Thickening, PFR Peak filling rate, DT: Mitral E wave deceleration time, IVRT: Isovolumic relaxation time.
  2. ¶ p < 0.05 vs controls. † p < 0.05 vs T2* > 20 ms by Bonferroni test
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Journal of Cardiovascular Magnetic Resonance

ISSN: 1532-429X

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