Figure 1

CMR techniques used for morphological and functional assessment. A: End-diastolic basal short-axis SSFP image of a healthy control, used for quantification of LV volumes and mass. B: LV basal short-axis end-diastolic HARM-image of the same patient as (A) with manually drawn epicardial (green) and endocardial (red) contours. By using Harmonic phase (HARP) analysis, myocardial deformation can be monitored throughout the cardiac cycle, allowing determination of left ventricular torsion and subendocardial circumferential strain (inner 50% of the LV wall) throughout the cardiac cycle. C: End-diastolic short axis SSFP image of a HCM mutation carrier, showing normal cardiac morphology and dimensions. D: LV short axis HARM-image of the same carrier as (C) acquired at end-systole.