- Oral presentation
- Open Access
The evaluation of right and left ventricular morphology by CMR with comparison to recipient heart after heart transplant: a surgical perspective
© Farber et al; licensee BioMed Central Ltd. 2011
- Published: 2 February 2011
- Interventricular Septum
- Pearson Product Moment Correlation
- Initial Validation
- Orthotopic Heart Transplantation
- Phantom Data
CMR is considered the ‘gold standard’ for non-invasive LV and RV mass quantitation. To our knowledge, this information is soley based on animal and phantom data never having been prospectively or retrospectively validated in humans, undermining its credibility. This issue is particularly important for the RV having complex geometry ill suited for mathematical modeling, placing increased importance on accurate mass quantitation. The surest way to validate the accuracy and thus the true gold standard of CMR derived mass is through autopsy but obviously is not feasible
To establish a correlation between CMR derived LV and RV mass vs autopsy mass of ex vivo hearts from transplants patients.
Over a 2 year period, 21 explanted cardiomyopathic hearts were obtained immediately upon orthotopic heart transplantation from the OR. They were quickly cleaned and suspended in a saline-filled container and scanned via SSFP-SA slices defining CMR LV mass (g) (GE 1.5 T, WI). The explanted hearts were then dissected shaving the atria off at the AV valve plane with ventricles surgically separated at the interventricular septum. The weight of the LV and RV was measured via high-fidelity scale for comparison with weighed mass of 17/21 hearts suitable for study.
The CMR measured LV mass (310±74.8g) significantly predicted the actual weighed LV mass (325±85g). The Pearson product moment (PPM) correlation was 0.95 (p<0.001). The CMR measured RV mass (178±76g) significantly predicted the actual RV mass (143±63g). The PPM correlation was 0.96 (p<0.001). The CMR measured LV + RV mass (495±131) significantly predicted actual LV + RV mass (467±27g). The PPM correlation for this sample was 0.97 (p<0.001). The equation y = 1.01x - 6.6b regressed the LV (r = 0.95).
CMR accurately determines LV and RV masses as compared to weighed explanted hearts, despite variable surgical removal of instrumentation (LVAD/RVAD, AICD's and often apical core removals) in the majority of hearts and the complexities of the RV in all. To our knowledge, albeit a small sample size, this represents a 'first' human CMR vs. autopsy comparison, similar to the intrepid days of initial validations of echocardiography vs. autopsy mass report by Reichek and Devereux in 1976.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.