Skip to main content

Endsystolic versus enddiastolic scar imaging for transmurality assessment


To investigate the influence of endsystolic scar imaging over routine enddiastolic scar imaging on transmurality.


The late gadolinium enhancement (LGE) technique has been an important achievement in cardiovascular magnetic resonance (CMR) and is widely used to precisely localize and determine the amount of necrosis and fibrosis. The percentage of transmurality of LGE is inversely related to the likelihood of functional recovery after revascularisation. LGE imaging is usually performed in enddiastole as recommended by current guidelines of the SCMR. Whether or not endsystolic imaging would significantly influence transmurality in patients with ischemic scarring remains unclear.


107 segments with moderate hypokinesia or more severe wall motion abnormalities were studied in 20 patients with established coronary artery disease referred for viability assessment (33% of all segments). We used a SSFP standard 4-chamber view to determine the endsystolic and enddiastolic position in the cardiac cycle. LGE imaging was performed with patient specific trigger delays to obtain enddiastolic (LGEed) and endsystolic (LGEes) images. Enddiastolic and endsystolic wall thickness (WTed and WTes), thickness of the remaining viable rim (RIMed and RIMes) and thickness of scar in enddiastole was measured manually.


Evidence of LGE was 84% in all dysfunctional segments with a mean scar of 3.4±2.5 mm. Total wall thickness and the thickness of the remaining viable myocardium increased from diastole to systole (WTed 7.9±1.9 versus WTes 8.4±2.2, p<0.001 ; RIMed 4.5±3.1 versus RIMes 5±3.4, p<0.001). There was a difference between the transmurality of scar measured in enddiastole and endsystole (LGEed 46±33% versus LGEes 44±33%, p<0.001). This difference was most pronounced in a subgroup of segments (n=50) between 25 and 75% transmurality of LGE (LGEed 57±18% versus LGEes 53±18%, p<0.001). Reduced transmurality was inversely correlated with increased thickness of the remaining viable rim between diastole and systole (r=-0.73).


Transmurality of scar changes little with varying acquisition times in the cardiac cycle. However there is a statistically significant difference between transmuralities derived from enddiastolic and endsystolic LGE imaging mainly due to the function of the remaining viable rim. Clinically this might not impact on decision making but clearly shows the importance of standardized imaging protocols especially in research studies.

Figure 1
figure 1

Differences between transmurality in enddiastole and endsystole. Red area indicates transmurality above 75% and green area below 25%.

Figure 2
figure 2

Differences between transmurality in enddiastole and endsystole. Especially in segments with intermediate transmurality this difference can be more extensive.

Table 1

Author information

Authors and Affiliations


Rights and permissions

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and permissions

About this article

Cite this article

Schuster, A., Chiribiri, A., Morton, G. et al. Endsystolic versus enddiastolic scar imaging for transmurality assessment. J Cardiovasc Magn Reson 13 (Suppl 1), P158 (2011).

Download citation

  • Published:

  • DOI: