Use of contrast-enhancement and high-resolution 3D black-blood MR Imaging to identify inflammation in rabbit atherosclerotic plaques
Journal of Cardiovascular Magnetic Resonance volume 13, Article number: P22 (2011)
Inflammation plays a critical role in plaque initiation, progression, and disruption. As such, inflammation represents an emerging target for the treatment of atherosclerosis.
We investigated the contributing factors for plaque enhancement and examined the relationships between regional contrast enhancement and the inflammatory activity of atherosclerotic plaques in an experimental rabbit model using contrast-enhanced high-resolution 3D black-blood magnetic resonance imaging (MRI) in comparison with histopathology.
Ten atherosclerotic rabbits and three normal control rabbits underwent high-resolution 3D contrast-enhanced black-blood MRI. MR images and the corresponding histopathological sections were divided into four quadrants. Plaque composition was analyzed for each quadrant according to histopathological (percent of lipid-rich, fibrous, macrophage area and microvessel density) and imaging criteria (enhancement ratio (ER), ER=SIpost/SIpre).
A total of 62 non-calcified plaques (n=248, 156 lipid-rich quadrants and 92 fibrous quadrants) were identified based on histopathology. Mean ER values were significantly higher in atherosclerotic vessel walls than in normal vessel walls (2.03 ± 0.25 vs 1.58 ± 0.15, p = 0.017). Mean ER values were significantly higher in macrophage-rich plaques compared to the macrophage-poor plaques (2.21 ± 0.28 vs 1.81± 0.22, p = 0.008). Using multiple regression analysis, macrophage area and microvessel density were independently associated with ER values that reflected plaque enhancement (p <0.001).
Contrast-enhanced high-resolution 3D black-blood MRI may be an efficient method to predict plaque inflammation.
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Hong, Y.J., Hur, J., Park, J. et al. Use of contrast-enhancement and high-resolution 3D black-blood MR Imaging to identify inflammation in rabbit atherosclerotic plaques. J Cardiovasc Magn Reson 13 (Suppl 1), P22 (2011). https://doi.org/10.1186/1532-429X-13-S1-P22
- Atherosclerotic Plaque
- Microvessel Density
- Enhancement Ratio
- Plaque Composition
- Plaque Inflammation