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Prevalence of left ventricular regional dysfunction differ in asymptomatic patients with systemic sclerosis compared to rheumatoid arthritis
Journal of Cardiovascular Magnetic Resonance volume 13, Article number: P318 (2011)
Background and purpose
In patients with systemic sclerosis (SSc) and rheumatoid arthritis (RA), cardiac involvements are common, may have serious consequences. Sensitive diagnostic techniques in cardiac MRI can identify subclinical myocardial abnormalities. The purpose of this study is to assess regional dysfunction of left ventricule in asymptomatic patients with SSc, compared to RA, by using unique image tracking method by using cine MRI.
The study population included 21 patients, 11 patients with SSc and 10 patients with RA, who underwent evaluation with cardiac MRI. Peak systolic regional radial strain (Err, %) was calculated by image tracking method by using cine MRI based on the 16-segment model (ZIOsoft, CA, USA).
Compared with RA subjects, SSc patients had similar LV ejection fraction, but peak systolic Err was less negative in all of 6 segments calculated by 16-segment model in SSc than RA. Peak systolic Err is; 1) antero-septal wall: 0.38+/-0.18 in RA and 0.24+/-0.14 in SSc (r=0.22), 2) infero-septal wall: 0.44+/-0.23 in RA and 0.29+/-0.13 in SSc (r=0.22), 3) inferior wall: 0.56+/-0.19 in RA and 0.38+/-0.14 in SSc (r=0.08), 4) infero-lateral wall: 0.57+/-0.25 in RA and 0.52+/-0.20 in SSc (r=0.57), 5) antero-lateral wall: 0.51+/-0.19 in RA and 0.45+/-0.30 in SSc (r=0.47), 6) anterior wall: 0.67+/-0.28 in RA and 0.41+/-0.31 in SSc (r=0.17).
SSc is associated with regional LV dysfunction in subclinical stage. Further large studies are needed to validate this finding and to better define implications of subclinical regional LV dysfunction.
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Yasuyuki, K., Lima, J.A., Lardo, A. et al. Prevalence of left ventricular regional dysfunction differ in asymptomatic patients with systemic sclerosis compared to rheumatoid arthritis. J Cardiovasc Magn Reson 13, P318 (2011). https://doi.org/10.1186/1532-429X-13-S1-P318
- Rheumatoid Arthritis
- Left Ventricule
- Asymptomatic Patient
- Systemic Sclerosis
- Cardiac Involvement