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Sustained cardiac remodeling after a short-term very low calorie diet in type 2 diabetes mellitus

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Journal of Cardiovascular Magnetic Resonance201113 (Suppl 1) :P328

https://doi.org/10.1186/1532-429X-13-S1-P328

  • Published:

Keywords

  • Public Health
  • Magnetic Resonance Imaging
  • Body Mass Index
  • Diabetes Mellitus
  • Cardiac Function

Introduction

A very low calorie diet (VLCD) in patients with type 2 diabetes mellitus (T2DM) results in cardiac remodeling and improved diastolic function. It is unknown how long these effects sustain after reintroduction of a regular diet.

Purpose

To examine the long-term effects of initial weight loss by a VLCD on cardiac dimensions and function in T2DM patients.

Methods

Fourteen patients with insulin-dependent T2DM (mean±SEM: age 53±2 years; BMI 35±1 kg/m2) were treated by a VLCD (450 kcal/day) during 16 weeks. Cardiac function was measured by magnetic resonance imaging before and after the 16-week VLCD and again after 14 months of follow-up on a regular diet.

Results

Body mass index decreased from 35±1 kg/m2 to 28±1 kg/m2 after the VLCD and increased again to 32±1 kg/m2 at 18 months (both P<0.05 vs. baseline). Left ventricular (LV) mass and LV mass/LV end-diastolic volume ratio decreased after the 16-week VLCD ((119±8 to 102±7grams; 0.67±0.03 to 0.59±0.03 respectively (both P<0.05)) and remained decreased after 14 months of follow-up (respectively 109±9 grams; 0.56±0.03, both P<0.05 vs. baseline) The improvement in LV diastolic function, measured by the early (E) and atrial (A) diastolic filling phase ratio after the 16-week VLCD, was sustained after 14 months of follow-up (E/A ratio: 0.96±0.07 (baseline); 1.12±0.06 (after VLCD); 1.06±0.07 (18 months, P<0.05 vs. baseline)).

Conclusions

Weight reduction by a 16-week VLCD in T2DM patients results in sustained cardiac remodeling and improved diastolic function after 14 months of follow-up, despite weight regain on a regular diet.

Authors’ Affiliations

(1)
LUMC, Leiden, Netherlands

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