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Sustained cardiac remodeling after a short-term very low calorie diet in type 2 diabetes mellitus

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Journal of Cardiovascular Magnetic Resonance201113 (Suppl 1) :P328

  • Published:


  • Public Health
  • Magnetic Resonance Imaging
  • Body Mass Index
  • Diabetes Mellitus
  • Cardiac Function


A very low calorie diet (VLCD) in patients with type 2 diabetes mellitus (T2DM) results in cardiac remodeling and improved diastolic function. It is unknown how long these effects sustain after reintroduction of a regular diet.


To examine the long-term effects of initial weight loss by a VLCD on cardiac dimensions and function in T2DM patients.


Fourteen patients with insulin-dependent T2DM (mean±SEM: age 53±2 years; BMI 35±1 kg/m2) were treated by a VLCD (450 kcal/day) during 16 weeks. Cardiac function was measured by magnetic resonance imaging before and after the 16-week VLCD and again after 14 months of follow-up on a regular diet.


Body mass index decreased from 35±1 kg/m2 to 28±1 kg/m2 after the VLCD and increased again to 32±1 kg/m2 at 18 months (both P<0.05 vs. baseline). Left ventricular (LV) mass and LV mass/LV end-diastolic volume ratio decreased after the 16-week VLCD ((119±8 to 102±7grams; 0.67±0.03 to 0.59±0.03 respectively (both P<0.05)) and remained decreased after 14 months of follow-up (respectively 109±9 grams; 0.56±0.03, both P<0.05 vs. baseline) The improvement in LV diastolic function, measured by the early (E) and atrial (A) diastolic filling phase ratio after the 16-week VLCD, was sustained after 14 months of follow-up (E/A ratio: 0.96±0.07 (baseline); 1.12±0.06 (after VLCD); 1.06±0.07 (18 months, P<0.05 vs. baseline)).


Weight reduction by a 16-week VLCD in T2DM patients results in sustained cardiac remodeling and improved diastolic function after 14 months of follow-up, despite weight regain on a regular diet.

Authors’ Affiliations

LUMC, Leiden, Netherlands


© Jonker et al; licensee BioMed Central Ltd. 2011

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.