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Long-term diet-induced, tissue-specific changes in (non)adipose triglyceride stores in obese patients with type 2 diabetes mellitus
Journal of Cardiovascular Magnetic Resonance volume 13, Article number: P352 (2011)
A very low calorie diet (VLCD) induces considerable weight loss in patients with type 2 diabetes mellitus, associated with improved insulin sensitivity and decreased triglyceride (TG) stores in (non)adipose tissues. Long-term effects of a VLCD on tissue-specific TG accumulation, including pericardial fat, have not been documented.
To assess the effects of a 16-week VLCD and of subsequent 14 months of follow-up on a regular diet on tissue-specific TG stores in obese type 2 diabetes patients.
We included 14 obese patients with insulin treated type 2 diabetes (mean±SEM: age 53±2 years; BMI 35±1 kg/m2). (Non)adipose TG stores were measured using magnetic resonance (MR) imaging and MR proton spectroscopy before and after a 16-week VLCD (Modifast, 450 kcal/day) and after a 14-month follow-up without dietary interventions.
A 16-week VLCD significantly reduced bodyweight, hepatic TG content, visceral and subcutaneous abdominal fat and pericardial fat volumes to 78, 16, 40, 55 and 83%, respectively, of baseline values (all p<0.05). After an additional 14 months of follow-up on a regular diet, weight and hepatic TG content increased significantly to 90 and 73% of baseline values (P<0.05). After these 14 months the preferential loss in visceral fat compared to subcutaneous abdominal fat was lost. In contrast, pericardial fat volume remained reduced to the same extent.
VLCD-induced weight loss and subsequent regain of weight during regular diet induces tissue-specific variations in (non)adipose TG stores in obese type 2 diabetes patients.
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Jonker, J.T., Snel, M., Hammer, S. et al. Long-term diet-induced, tissue-specific changes in (non)adipose triglyceride stores in obese patients with type 2 diabetes mellitus. J Cardiovasc Magn Reson 13, P352 (2011). https://doi.org/10.1186/1532-429X-13-S1-P352
- Improve Insulin Sensitivity
- Regular Diet
- Calorie Diet
- Preferential Loss
- Obese Type