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Proximal aortic stiffness in the paediatric adolescent population


The aim of this study was to assess whether arterial stiffness increases in the second decade of life.


Pathological studies have shown that atherosclerotic disease begins in early childhood. Furthermore, associations between risk factors and early atherosclerotic disease are evident in this population and therefore may be linked to future symptomatic coronary events.

While we have shown that ageing preferentially stiffens the proximal aorta in an adult population, it is uncertain whether this also occurs in an adolescent cohort.


The evaluation of arterial stiffness was performed by gated magnetic resonance imaging (MRI, 1.5T Siemens Sonata) TrueFISP (fast imaging with steady state free precession) cine sequence with off-line analysis (Image-Pro Plus, MediaCyberkinetics, USA). Cross-sectional measurements of aortic areas (mm2) were undertaken at 3 locations: the ascending (AA), proximal descending (PDA) and distal descending aorta (DDA). Arterial stiffness was evaluated by aortic distensibility [(maximal aortic area - minimal aortic area)/(brachial pulse pressure X minimal aortic area)].


Ten paediatric (10.6±2.3 years) and ten young adults (20.3±0.5 years) underwent cardiovascular magnetic resonance assessment of arterial stiffness.


This is the first study to demonstrate a similar pattern of heterogenous stiffening occurring as early as the 2nd decade. These results must be interpreted in the context of this study being cross sectional in nature and involving only a small number of subjects. Nonetheless these findings warrant further assessment through a prospective, longitudinal study to further evaluate this parameter as a potential unique early marker of future cardiovascular events.

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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Nelson, A.J., Cameron, J.D., Kaihui, A.C. et al. Proximal aortic stiffness in the paediatric adolescent population. J Cardiovasc Magn Reson 13 (Suppl 1), P389 (2011).

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