Volume 13 Supplement 1

Abstracts of the 2011 SCMR/Euro CMR Joint Scientific Sessions

Open Access

Epicardial fat volume is associated with coronary endothelium-dependent vasomotor response in healthy subjects

  • Bénédicte Gaborit1,
  • Pierre Julien Moro2,
  • Antonin Flavian3,
  • Frank Kober3,
  • Alexis Jacquier3,
  • Jacques Quilici4,
  • Thomas Cuisset5,
  • Umberto Simeoni6,
  • Patrick Cozzone3,
  • Monique Bernard3 and
  • Anne Dutour1
Journal of Cardiovascular Magnetic Resonance201113(Suppl 1):P71

https://doi.org/10.1186/1532-429X-13-S1-P71

Published: 2 February 2011

Introduction

Epicardial fat (Efat) is an active ectopic fat depot, directly surrounding coronary arteries, and secreting high level of inflammatory adipokines; its development has been associated with coronary atherosclerosis. We investigated the relationship between Efat and endothelium dependent vasoreactivity of the coronary microcirculation.

Methods

Myocardial blood flow (MBF) was determined by measuring coronary sinus flow with velocity-encoded cine magnetic resonance imaging at 3 teslas. We measured MBF at baseline and in response to sympathetic stimulation by cold pressor testing (CPT) in 17 healthy volunteers with normal left ventricular function (age 24±6 years, BMI=21.1±2.6kg/m2). Efat volume was volumetrically assessed by manual delineation on short-axis views. CPT was applied by immersing one foot in ice water for 4 minutes.

Results

A significant increase in MBF was observed: 1.18±0.58 vs 0.84±0.47mL.min-1.g-1, CPT vs rest, p=0.002. Mean relative MBF increase (ΔMBF) was 50±47%. Mean Efat volume was 82±31mL and varied from 43 to 131 mL; mean LV mass and Left ventricular ejection fraction were 104±31g and 64±5%, respectively. CPT significantly increased heart rate (HR) by 28±13%, systolic blood pressure (BP) by 17±13%, diastolic BP by 23±19% and rate-pressure product by 52±25%, p<0.01, indicating an increase in myocardial work load. The increase in HR, reflecting sympathetic stimulation, was not influenced by sex, age or Efat volume. CPT induced a decrease in coronary vascular resistance (150±93 vs 114±44 mmHg.mL-1.min.g) by trend (p=0.08). Interestingly, we found a significant negative correlation between Efat volume and ΔMBF (r=-0.51, p=0.03), which remained significant after adjusting for age and sex. ΔMBF was not associated with waist circumference, BMI, CRP, lipid or glycemic parameters.

Conclusion

The increase in Efat is associated with a decrease in endothelium dependent vasoreactivity response, suggesting that Efat could early influence endothelial function.

Authors’ Affiliations

(1)
INSERM U626, Marseille, F-13385 France, Centre de Résonance Magnétique Biologique et Médicale (CRMBM), CNRS UMR 6612, Department of Endocrinology, Metabolic Diseases and Nutrition, CHU Nord, Marseille, France
(2)
Centre de Résonance Magnétique Biologique et Médicale
(3)
Centre de Résonance Magnétique Biologique et Médicale (CRMBM), CNRS UMR 6612
(4)
Department of Cardiology, CHU Timone, Marseille, France
(5)
INSERM U626, Marseille, F-13385 France , Department of Cardiology, CHU Timone, Marseille, France
(6)
Department of Neonatalogy, Children and Parents Pole, CHU Timone, Marseille, France

Copyright

© Gaborit et al; licensee BioMed Central Ltd. 2011

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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