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The ischemic area-at-risk on T2-weighted MRI shows recovery of systolic strain at 1 year


Animal models have demonstrated a recovery in systolic strain following reperfusion of acutely ischemic myocardium, however this has not been shown in clinical practice.


We aimed to determine whether there was long term improvement of regional strain in acutely ischemic myocardium following primary coronary intervention using cardiac magnetic resonance imaging (CMR)


We studied 16 patients with acute ST elevation myocardial infarction (STEMI) who had received successful primary coronary intervention (PCI) to the culprit coronary artery. CMR was performed on a 1.5T Philips Achieva system (Best, Netherlands) within 7 days of PCI and again at 1 year. We used segmentation of T2-weighted spectrally-selective inversion recovery (SPIR) imaging to detect the ischemic area-at-risk and delayed enhancement inversion recovery imaging to measure infarct size and transmural thickness. Complementary spatial modulation of magnetization (CSPAMM) tagging with harmonic phase analysis (HARP) was used to measure peak midwall systolic strain at baseline and follow-up. Each section was divided according to the American Heart Association classification providing a total of 96 myocardial segments for analysis at each visit.


All patients showed acute myocardial edema within the reperfused territory and a variable transmural extent of enhancing necrosis. Mean myocardial salvage, given as the proportion of viable myocardium within the ischemic area-at-risk, was 62±21% at baseline. The mean infarct area at baseline was 20±10.2% and 14±5.7% at 1 year follow-up. In total 45 segments showed enhancing necrosis and the peak systolic midwall circumferential strain (Ecc) improved between baseline and follow-up ( -14.4±5.3% vs -19.2±5.4%, p<0.0001). In the remaining non-infarcted 45 segments there was no change in Ecc (-18.7±6.8% vs -21.1±6.1%, NS). The mean radial transmural extent of necrosis showed no correlation with ΔEcc (r2=0.01, NS).


These findings demonstrate a long-term improvement in systolic function in acutely ischemic reperfused myocardium.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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O'Regan, D.P., Ariff, B., Neuwirth, C. et al. The ischemic area-at-risk on T2-weighted MRI shows recovery of systolic strain at 1 year. J Cardiovasc Magn Reson 13 (Suppl 1), P90 (2011).

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