Heme arginate improves reperfusion patterns after ischemia: a randomized, placebo-controlled trial in healthy male subjects

Table 2 BOLD signal of calf muscles after ischemia-reperfusion injury

All muscles	TTP (s)	PEAK (%)	slope (1/s)
placebo	221±19	104.5±0.6	−2.110^-4±0.210^-4
HA	175±16	106.2±0.6	−2.810^-4±0.210^-4
p-value	0.012	0.025	0.002
gastrocnemius
placebo	250±36	102.6±0.8	−1.610^-4±0.210^-4
HA	198±11	104.0±0.6	−2.210^-4±0.210^-4
soleus
Placebo	244±31	106.5±0.7	−2.610^-4±0.410^-4
HA	182±8	107.8±0.8	−3.210^-4±0.410^-4
Tibialis ant.
Placebo	169±28	104.3±1.2	−2.010^-4±0.310^-4
HA	152±13	106.9±1.5	−3.010^-4±0.410^-4

Heme arginate or placebo were administered 24 hours prior to ischemia. Data are mean±SD, n = 11; p-value was calculated using a general linear mixed model and applies to all comparisons, since interaction analysis suggested homogeneity of the treatment effect across muscles. TTP: time to peak; PEAK: peak reperfusion signal; slope: slope of the tangent at the inflection point of the BOLD signal curve after the peak; HA: heme arginate.

ISSN: 1532-429X