- Poster presentation
- Open Access
Ascending aorta backward flow parameters estimated from phase-contrast cardiovascular magnetic resonance data: new indices of arterial aging
© Bensalah et al; licensee BioMed Central Ltd. 2012
- Published: 1 February 2012
- Pulse Wave Velocity
- Arterial Aging
- Aortic Stiffness
- Ascend Aorta
- Cardiovascular Magnetic Resonance Data
Our purpose was to estimate volume and flow rate parameters related to the backward flow in the ascending aorta (AA) using phase-contrast cardiovascular magnetic resonance (PC-CMR) and to evaluate their relationships with age and with well established arterial stiffness indices including wave reflection parameters in an asymptomatic group without overt cardiovascular disease.
Aging is a major risk factor for cardiovascular disease and is a prime determinant of aortic stiffness. Backward flow has been previously described using PC-CMR, but only few studies focused on the comparison between backward flow parameters and arterial stiffness indices.
Mean values were: 70.2 ± 22.4 ml for the aortic systolic forward volume and 13.2 ± 9.4 ml for the backward volume VB. Mean value of QBmax was 55.8 ± 27.5 ml/sec. While non-significant correlations were found for the comparisons against age of forward flow parameters VF (r=0.25, p=0.03) and QFmax (r=0.23, p=0.025), significant correlations were obtained with age for backward flow parameters VB (r=0.63, p<0.0001) and QBmax (r=0.55, p<0.0001). VB also significantly correlated with arterial stiffness indices (Table). Similar results were obtained when considering QBmax.
AA backward flow parameters estimated from PC-CMR significantly correlated with age as well as with conventional arterial stiffness indices. These backward flow parameters, which can be easily estimated using an automated analysis of PC-CMR data, could, when combined with parameters of left ventricular (LV) function, help to increase the understanding of arterial aging and LV-arterial coupling mechanisms.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.