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- Open Access
Comparison of systolic and diastolic criteria for isolated left ventricular noncompaction in cardiac MRI
© Stacey et al; licensee BioMed Central Ltd. 2012
- Published: 1 February 2012
- Ejection Fraction
- Congestive Heart Failure
- Cardiac Magnetic Resonance
- Cardiac Magnetic Resonance Imaging
- Lower Ejection Fraction
Interest in left ventricular non-compaction (LVNC) as a distinct clinical form of cardiomyopathy is supported by recent publications. Echocardiographic and select cardiac MRI criteria have been established which are used to facilitate the diagnosis and have led to concerns of diagnostic accuracy. We used cardiac magnetic resonance imaging (cMRI) to assess standard criteria for LVNC.
Trabeculation/ possible LVNC by cMRI was retrospectively observed among 122 consecutive cases and comprised our study population. We compared standard end systolic (ES) and end diastolic (ED) criteria previously established along with myocardial thickening (MT), ejection fraction (EF), 3D sphericity index (3DS), and LV end-diastolic volume index (EDVi). Using analysis of covariance, adjusted means for EF, MT, and 3DS were generated by adjusting for age, race, gender, body surface area (BSA), diabetes mellitus, hypertension, hyperlipidemia, coronary artery disease, and congestive heart failure (CHF). Adjusting for these same covariates except CHF, logistic regression was used to compare the odds of CHF for those who met criteria for NC at ES vs. those at ED.
ES noncompacted: compacted ratio (NCCR) had stronger correlations with MT (-0.49), EF (-68), EDVi (0.63), and 3DS (0.55) than the ED NCCR (MT: -0.22; EF: -0.25; EDVi: 0.37; 3DS: 0.32). After adjustment for covariates, those who met criteria for NC by ES NCCR had a lower EF (p=0.01) and less MT than those who did not (p =0.01 and p=0.003, respectively), but there was no statistical difference in EF or MT between those who met criteria for ED NCCR and those who did not. The odds ratio of CHF for those who met ES NCCR criteria was 29.4 (CI: 6.6-125), but the odds ratio of CHF for those who met ED NCCR criteria was 3.3 (CI: 1.1-9.2).
ES measures of NC have stronger associations with systolic dysfunction and CHF than the ED measures.
Comparison of Ejection Fraction and Myocardial Thickening between End-Systolic and End-Diastolic Criteria for Noncompaction in Cardiac MRI
Ejection Fraction (%)
ES NC:C Ratio > 2
31.8 ± 6
9.4 ± 16.2
ES NC:C Ratio < 2
40.4 ± 8.8
37.2 ± 12
ED NC:C Ratio > 2.3
36.4 ± 5.4
37.3 ± 12.3
ED NC:C Ratio < 2.3
38.4 ± 4.5
27.0 ± 14.8
Odds Ratios for Congestive Heart Failure by Noncompaction:Compaction Ratio
Odds Ratio (95% Confidence Interval)
End-Systolic Noncompacted:Compacted Ratio (Continuous Variable)
20.9 (5.7 - 76.7)
End-Diastolic Noncompacted:Compacted Ratio (Continuous Variable)
3.3 (1.4 - 8.0)
End-Systolic Noncompacted:Compacted Ratio > 2
29.4 (6.6 - 125)
End-Diastolic Noncompacted:Compacted Ratio > 2.3
3.3 (1.13 - 9.2)
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.