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  • Open Access

Comparison of systolic and diastolic criteria for isolated left ventricular noncompaction in cardiac MRI

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Journal of Cardiovascular Magnetic Resonance201214 (Suppl 1) :P148

  • Published:


  • Ejection Fraction
  • Congestive Heart Failure
  • Cardiac Magnetic Resonance
  • Cardiac Magnetic Resonance Imaging
  • Lower Ejection Fraction


Interest in left ventricular non-compaction (LVNC) as a distinct clinical form of cardiomyopathy is supported by recent publications. Echocardiographic and select cardiac MRI criteria have been established which are used to facilitate the diagnosis and have led to concerns of diagnostic accuracy. We used cardiac magnetic resonance imaging (cMRI) to assess standard criteria for LVNC.


Trabeculation/ possible LVNC by cMRI was retrospectively observed among 122 consecutive cases and comprised our study population. We compared standard end systolic (ES) and end diastolic (ED) criteria previously established along with myocardial thickening (MT), ejection fraction (EF), 3D sphericity index (3DS), and LV end-diastolic volume index (EDVi). Using analysis of covariance, adjusted means for EF, MT, and 3DS were generated by adjusting for age, race, gender, body surface area (BSA), diabetes mellitus, hypertension, hyperlipidemia, coronary artery disease, and congestive heart failure (CHF). Adjusting for these same covariates except CHF, logistic regression was used to compare the odds of CHF for those who met criteria for NC at ES vs. those at ED.


ES noncompacted: compacted ratio (NCCR) had stronger correlations with MT (-0.49), EF (-68), EDVi (0.63), and 3DS (0.55) than the ED NCCR (MT: -0.22; EF: -0.25; EDVi: 0.37; 3DS: 0.32). After adjustment for covariates, those who met criteria for NC by ES NCCR had a lower EF (p=0.01) and less MT than those who did not (p =0.01 and p=0.003, respectively), but there was no statistical difference in EF or MT between those who met criteria for ED NCCR and those who did not. The odds ratio of CHF for those who met ES NCCR criteria was 29.4 (CI: 6.6-125), but the odds ratio of CHF for those who met ED NCCR criteria was 3.3 (CI: 1.1-9.2).


ES measures of NC have stronger associations with systolic dysfunction and CHF than the ED measures.


No funding source used for this project.
Table 1

Comparison of Ejection Fraction and Myocardial Thickening between End-Systolic and End-Diastolic Criteria for Noncompaction in Cardiac MRI


Ejection Fraction (%)


Myocardial Thickening(%)


ES NC:C Ratio > 2

31.8 ± 6


9.4 ± 16.2


ES NC:C Ratio < 2

40.4 ± 8.8


37.2 ± 12


ED NC:C Ratio > 2.3

36.4 ± 5.4


37.3 ± 12.3


ED NC:C Ratio < 2.3

38.4 ± 4.5


27.0 ± 14.8


Analysis of covariance used to generate adjusted means with 95% confidence interval. Adjusted for age, race, gender, BSA, diabetes mellitus, hypertension, hyperlipidemia, coronary artery disease, and congestive heart failure.

Table 2

Odds Ratios for Congestive Heart Failure by Noncompaction:Compaction Ratio


Odds Ratio (95% Confidence Interval)


End-Systolic Noncompacted:Compacted Ratio (Continuous Variable)

20.9 (5.7 - 76.7)

< 0.001

End-Diastolic Noncompacted:Compacted Ratio (Continuous Variable)

3.3 (1.4 - 8.0)


End-Systolic Noncompacted:Compacted Ratio > 2

29.4 (6.6 - 125)

< 0.001

End-Diastolic Noncompacted:Compacted Ratio > 2.3

3.3 (1.13 - 9.2)


Logistic regression analysis used to generate odds-ratios for congestive heart failure. Adjusted for age, race, gender, BSA, diabetes mellitus, hypertension, hyperlipidemia, coronary artery disease.

Authors’ Affiliations

Cardiology, Wake Forest University School of Medicine, Winston-Salem, NC, USA


© Stacey et al; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.