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Short inversion time on delayed-enhancement magnetic resonance improves diagnostic accuracy in recent-onset heart failure
Journal of Cardiovascular Magnetic Resonance volume 14, Article number: P188 (2012)
We evaluated the diagnostic consistency of a short inversion time (TI) Late Gadolinium Enhancement (LGE) sequence in the diagnostic work-up of recent onset heart failure of ischemic aetiology
Subendocardial LGE is a marker of ischemic aetiology of left ventricular dysfunction, and of viable myocardium. Using a high relaxivity contrast media such as gadobenate dimeglumine, however, little areas of subendocardial LGE can be masked by the high signal of the blood pool. We halved the optimal TI to null the signal of viable myocardium to obtain LGE images with high signal from viable myocardium, intermediate signal from the blood pool, and no signal from LGE areas, thus enhancing the presence of “hidden areas” subendocardial enhancement.
23 patients with recent-onset heart failure (62 +/-11 years) were studied with CMR after contrast media administration ( MultiHance, Bracco) using LGE and short TI LGE sequences. All patients underwent invasive coronary angiography. Images were analyzed by an experienced (> 8 years of CMR reading)and 2 less experiences ( <18 months of CMR readings) readers, searching for the presence of areas of subendocardial enhancement.
17 patients had critical coronary artery disease at angiography. No one of the remaining 6 patients showed subendocardial enhancement. Of the 17 truly ischemic patients, 8 had areas > 25% subendocardial LGE, detected by all readers. In the 9 pts with <25% subendocardial LGE, a correct diagnosis was made in 8/9 by experienced reader and 6/9 by less experienced readers using normal TI. Short TI allowed all readers to detect < 25% subendocardial fibrosis in 9/9 patients.
Short TI LGE significantly improves the diagnostic accuracy for ischemic aetiology of heart failure, with a greater improvement in less experienced readers. In our small series of ischemic patients without transmural myocardial infarction, short TI LGE allowed to detect subendocardial fibrosis also in patients "without" subendocardial LGE.
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Monti, L., Nardi, B., Lisignoli, V. et al. Short inversion time on delayed-enhancement magnetic resonance improves diagnostic accuracy in recent-onset heart failure. J Cardiovasc Magn Reson 14, P188 (2012). https://doi.org/10.1186/1532-429X-14-S1-P188
- Late Gadolinium Enhancement
- Viable Myocardium
- Invasive Coronary Angiography
- Experienced Reader
- Gadobenate Dimeglumine