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- Open Access
Magnetic resonance imaging pre and post pulmonary vein isolation for atrial fibrillation: diagnostic accuracy to detect and characterize ablation lesions
© Jones et al; licensee BioMed Central Ltd. 2012
- Published: 1 February 2012
- Cardiovascular Magnetic Resonance
- Late Gadolinium Enhancement
- Pulmonary Vein Isolation
- Late Gadolinium Enhancement Imaging
- Ablation Lesion
LGE imaging of left atrial scar is promising and can detect pre/post ablation procedures however further quality control required to accurately depict lesion distribution
We tested the hypothesis that cardiovascular magnetic resonance (CMR) imaging can reliably distinguish the presence or absence of ablation lesions by blinded analysis of pre and post ablation imaging.
Consecutive patients with paroxysmal AF in a randomised study comparing pulmonary vein isolation by wide area circumferential radiofrequency ablation (WACA) to ostial ablation with a cryo-balloon (CRYO) underwent CMR late gadolinium enhancement (LGE) imaging pre- and 3 months post ablation. Imaging was anonymized for blinded analysis of (1) LGE images, and (2) a 3D fusion image with LGE projected onto a segmented LA surface (thresholding set at 5 SD above mean ventricular signal). Scans were categorised using both assessment techniques separately as pre or post ablation, and if post ablation, whether lesions were in an ostial or WACA distribution.
LGE imaging was performed in 50 patients (aged 61 ± 10 years, 72% male). Sensitivity and specificity for detection of ablation lesions was 60% and 96% on LGE imaging, or 88% and 82% respectively on 3D fusion imaging. Detection of WACA and CRYO lesion sets were correct in 14/24 and 16/26 respectively on LGE imaging, or 21/24 and 23/26 on 3D fusion imaging. Assessment of lesion distribution was correct for 13/50 from LGE images (4/24 for WACA and 9/26 for CRYO) and 26/50 from 3D fusion images (p = 0.013; 13/24 for WACA and 13/26 for CRYO).
LGE imaging of atrial scar after ablation therapy is feasible. The technique still needs quality control standards established in order to determine the appropriate SD setting and to judge whether lack of peri-ostial scar is due to a sub-optimal scan or myocardial recovery
Diagnostic accuracy of detecting atrial scarring in blinded analysis of pre and post ablation MR images.
Late Gadolinium Enhancement
Segmented Fusion images
Accuracy of MR images to locate atrial scarring according to ablation technique
Correct identification of lesion distribution
Fusion segmented image
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.