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  • Open Access

Simultaneous assessment of myocardial scar and coronary artery disease by navigator-gated 3D fat-suppressed delayed-enhancement CMR: comparison with 2D delayed-enhancement CMR, CT and CAG

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Journal of Cardiovascular Magnetic Resonance201214 (Suppl 1) :P302

https://doi.org/10.1186/1532-429X-14-S1-P302

  • Published:

Keywords

  • Coronary Artery Disease
  • Coronary Artery
  • Myocardial Perfusion
  • Coronary Artery Stenosis
  • Ischemic Cardiomyopathy

Summary

The aim of this study was to assess the feasibility of navigator-gated 3D fat-suppressed delayed-enhancement CMR (DE-CMR) for simultaneous assessment of the myocardial scar and coronary artery disease, by comparing with 2D DE-CMR, CT, and CAG.

Background

Simultaneous assessment of myocardial scar or perfusion reduction and coronary artery stenosis is currently performed by side-by-side comparison or image fusion using coronary CTA and myocardial perfusion study, but the misregistration and differences in spatial resolution between imaging methods can be problematic. A CMR technique that can visualize both myocardial scar and coronary artery disease during a single examination may resolve this problem.

Methods

Sixteen patients underwent a navigator-gated 3D fat-suppressed DE-CMR using a 3.0T imager. The spatial resolution of this imaging was 1.5x1.25x3.0-3.4 mm3 before an interpolation. Inversion recovery and spectrally-selective pulses were used to suppress normal myocardial and epicardial fat signals, respectively. The ability of the navigator-gated 3D fat-suppressed DE-CMR to detect myocardial scar was compared with that of 2D DE-CMR. The signal reduction of coronary artery on the 3D DE-CMR was compared with calcified plaques on CT (n = 13) and significant stenosis (> 75%) on CAG (n = 8). The relationship between myocardial scar and coronary arteries was also assessed in six patients with ischemic cardiomyopathies.

Results

Twenty-five myocardial scars on 2D DE-CMR, 66 coronary calcified lesions on CT, and six coronary stenoses on CAG were investigated in 16 patients. The navigator-gated 3D fat-suppressed DE-CMR detected 25 (92.6%) scars, 43 (65.1%) arterial signal reduction, and three (50%) coronary artery stenoses. When excluding the coronary arteries that were affected by respiratory artifacts, 84.3% of coronary artery diseases were detected by the 3D-CMR. This imaging showed the diffuse stenoses of coronary arteries, comparable to diffuse calcified plaques, in the patients with ischemic cardiomyopathy.

Conclusions

Navigator-gated 3D fat-suppressed DE-CMR was feasible for simultaneous assessment of the myocardial scar and coronary arteries with calcified plaques.

Funding

No disclosure for this presentation.
Figure 1
Figure 1

Navigator-gated 3D fat-suppressed DE-CMR shows myocardial scar following infarction.

Figure 2
Figure 2

Navigator-gated 3D fat-suppressed DE-CMR shows signal reduction of coronary arteries simultaneously.

Authors’ Affiliations

(1)
Nippon Medical School, Tokyo, Japan

Copyright

© Amano et al; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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