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Myocardial perfusion MRI using SW-CG-HYPR for the detection of coronary artery disease


In this work, we have prospectively examined the diagnostic value of adenosine-induced stress myocardial perfusion MRI using SW-CG-HYPR in 50 patients with suspected CAD. Using the high-resolution, whole left ventricle SW-CG-HYPR method, perfusion MRI was able to depict hemodynamically relevant coronary artery stenosis with an accuracy of 90% and 93% based on per-patient and per-vessel analyses, respectively, using x-ray coronary angiography as the reference standard.


Myocardial perfusion MRI with SW-CG-HYPR allows increased spatial coverage (whole left ventricular coverage), improved temporal and spatial resolution and signal-to-noise ratio, and reduced motion artifacts. The accuracy of this technique for detecting coronary artery disease (CAD) has not been determined in a large number of patients. The purpose of this study was to prospectively evaluate the diagnostic performance of myocardial perfusion MRI with SW-CG-HYPR in patients with suspected CAD.


Fifty consecutive patients (28 men and 22 women; mean age, 56 ± 16 years) who were scheduled for coronary angiography with suspected CAD underwent myocardial perfusion MRI with SW-CG-HYPR at 3.0T. Perfusion defects were interpreted qualitatively by 2 blinded observers and were correlated to x-ray angiographic stenoses ≥ 50%.


The prevalence of CAD was 56%. In the per-patient analysis, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of SW-CG-HYPR myocardial perfusion imaging were 96% (95% confidence interval [CI] 82% to 100%), 82% (95% CI 60% to 95%), 87% (95% CI 70% to 96), 95% (95% CI 74% to100%), and 90% (95% CI 82% to 98%), respectively. In the per-vessel analysis, these values were 98% (95% CI 91% to 100%), 89% (95% CI 80% to 94%), 86% (95% CI 76% to 93%), 99% (95% CI 93% to 100%), and 93% (95% CI 89% to 97%), respectively.


Myocardial perfusion MRI using SW-CG-HYPR allows whole left ventricular coverage and high resolution, and has high diagnostic accuracy in patients with suspected CAD.


This work was supported by National Institute of Health (NIBIB EB002623) and National Natural Science Foundation of China (30828009).

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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yang, J., Ma, H., Liu, J. et al. Myocardial perfusion MRI using SW-CG-HYPR for the detection of coronary artery disease. J Cardiovasc Magn Reson 14 (Suppl 1), T5 (2012).

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