Table 1 Genetically confirmed HFE-HC patient group: patient characteristics at time of CMR scan

Number of patients

31

Male/Female

25/6

Age (years): mean [SD]

58.8 [13.6]

Weight (kg): mean [SD]

80.8 [14.5]

Height (cm): mean [SD]

173 [11.8]

Race

Caucasian

31

Genetic mutation analysis: N (%)

C282Y/C282Y

30 (97%)

C282Y/H63D

1 (3%)

Presentation ferritin (μg/L): median [Q1, Q3]; Normal 30-400

1286 [639, 2772]

Iron (μmol/L): mean [SD]; Normal 9-30

43.5 [12.7]

Iron binding saturation (%): mean [SD]; Normal 25-50

67.5 [19.8]

Hb (g/dL): mean [SD]; Normal 13-15

13.6 [1.4]

Liver T2* (ms): median [Q1, Q3]; Normal 26.7 ±4.2 ms

3.0 [1.4, 7.3]

Liver iron concentration (mg/g dw): median [Q1, Q3]

8.7 [3.7, 18.3]

LV EDV/BSA (mL/m²): median [Q1, Q3]; Normal 60-95

77 [64, 88]

LV ESV/BSA (mL/m²): median [Q1, Q3]; Normal 16-36

24 [20, 29]

LV EF (%): median [Q1, Q3]; Normal 58-76

70 [59, 73]

LV mass/BSA (g/m²): median [Q1, Q3]; Normal 53-84

70 [58, 90]

Cardiac T2* (ms): median [Q1, Q3]; Normal 40 ms

34.8 [25.4, 40.1]

Cardiac iron concentration (mg/g dw): median [Q1, Q3]

0.59 [0.50, 0.87]