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Table 2 Initial modeling with relevant parameters thought to influence aortic diameter in Turner syndrome in a cohesive mathematical model

From: Prediction of aortic dilation in Turner syndrome - enhancing the use of serial cardiovascular magnetic resonance

Variable

CoA

Age

BAV

Antihypertensive treatment

Diastolic ABP

BSA

ERT duration

Karyotype

ETA

Position

Aortic sinus

0.04

0.0030

0.100

−0.041

−0.0006

0.17

0.0020

−0.06

0.0357

(−0.04 - 0.12)

(0.0005 – 0.0056)

(0.038 – 0.160)

(−0.067 - -0.015)

(−0.0017 – 0.0005)

(−0.01 – 0.35)

(−0.0007 – 0.0046)

(−0.12 - -0.01)

(−0.0208 – 0.0923)

Sinotubular junction

−0.02

0.0031

0.129

−0.007

−0.0005

0.06

0.0017

−0.08

0.0165

(−0.11 – 0.08)

(0.0003 – 0.0059)

(0.055 – 0.203)

(−0.034 – 0.018)

(−0.0017 – 0.0006)

(−0.14 – 0.25)

(−0.0013 – 0.0047)

(−0.14 - -0.01)

(−0.0515 – 0.0846)

Mid-ascending aorta

−0.06

0.0060

0.174

−0.010

0.0008

0.05

−0.0003

−0.06

0.0115

(−0.16 – 0.04)

(0.0032 – 0.0089)

(0.097 – 0.252)

(−0.034 – 0.014)

(−0.0003 – 0.0018)

(−0.14 – 0.24)

(−0.0034 – 0.0027)

(−0.13 – 0.01)

(−0.0598 – 0.0828)

Distal ascending aorta

−0.03

0.0045

0.078

0.003

0.0008

0.10

−0.0022

−0.03

−0.00001

(−0.11 – 0.05)

(0.0021 – 0.0068)

(0.015 – 0.141)

(−0.018 – 0.024)

(−0.0001 – 0.0017)

(−0.06 – 0.26)

(−0.0048 – 0.0003)

(−0.09 – 0.02)

(−0.0580 – 0.0579)

Proximal aortic arch

−0.07

0.0034

0.081

−0.012

0.0001

0.17

−0.0032

−0.05

−0.0108

(−0.16 – 0.02)

(0.0009 – 0.0059)

(0.016 – 0.145)

(−0.037 – 0.014)

(−0.0011 – 0.0013)

(−0.001 – 0.35)

(−0.0058 – 0.0005)

(−0.11 – 0.01)

(−0.0702 – 0.0487)

Mid aortic arch

−0.06

0.0009

0.008

−0.008

0.0009

0.16

−0.0009

−0.02

−0.0456

(−0.14 – 0.02)

(−0.0013 – 0.0032)

(−0.051 – 0.067)

(−0.029 – 0.013)

(−0.0001 – 0.0018)

(−0.002 – 0.31)

(−0.0033 – 0.0015)

(−0.07 – 0.04)

(−0.1000 – 0.0088)

Distal transverse aortic arch

−0.02

0.0026

0.024

0.006

0.0016

0.19

−0.0006

−0.03

−0.0241

(−0.08 – 0.05)

(0.0006 – 0.0046)

(−0.025 – 0.073)

(−0.016 – 0.027)

(0.0007 – 0.0025)

(0.04 – 0.33)

(−0.0027 – 0.0016)

(−0.08 – 0.01)

(−0.0692 – 0.0210)

Proximal descending

0.21

0.0007

0.051

−0.014

0.0009

0.12

0.0001

−0.04

0.0037

(0.13 – 0.29)

(−0.0016 – 0.0030)

(−0.009 – 0.110)

(−0.034 – 0.006)

(−0.0001 – 0.0017)

(−0.04 – 0.27)

(−0.0024 – 0.0025)

(−0.10 – 0.01)

(−0.0508 – 0.0583)

Distal descending aorta

0.14

0.0034

0.047

0.010

0.0014

0.20

−0.0008

−0.04

−0.0163

(0.07 – 0.20)

(0.0016 – 0.0052)

(−0.0005 – 0.0094)

(−0.008 – 0.028)

(0.0006 – 0.0021)

(0.07 – 0.32)

(−0.0027 – 0.0012)

(−0.08 – 0.005)

(−0.0597 – 0.0270)

P value

<0.0001

<0.0001

0.0004

0.005

0.0008

0.02

0.08

0.2

0.4

  1. The β estimates (95% confidence interval) are presented for each aortic position, and at the bottom of the table the p-value indicates whether the parameter influences the thoracic aorta at any point.
  2. Abbreviations: COARC Aortic coactation, BITRI the presence of bicuspid aortic valve, ABP ambulatory blood pressure, BSA Body surface area, ERT oestrogen replacement therapy.
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Journal of Cardiovascular Magnetic Resonance

ISSN: 1532-429X

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