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Assessment of coronary artery disease using 3.0 T magnetic resonance coronary angiography: a national multicenter trial
Journal of Cardiovascular Magnetic Resonance volume 15, Article number: E5 (2013)
3.0T contrast enhanced whole-heart coronary magnetic resonance angiography (MRA) is a promising method for noninvasive, radiation-free detection and exclusion of obstructive coronary artery disease (CAD); however, the accuracy of this approach has not been determined in a multicenter trial.
An ECG-triggered, navigator-gated, inversion-recovery prepared, segmented gradient-echo sequence was used for image acquisition in 272 patients with suspected CAD at 8 hospitals. The accuracy of coronary MRA for detecting a 50% diameter reduction was determined using X-ray coronary angiography as the reference method. Using an intention-to-diagnose approach, all coronary arteries were included for the evaluation regardless of the image quality of coronary MRA to avoid overestimation of the diagnostic accuracy. Clinical Trial Registration—URL: http://clinicaltrials.gov. Unique identifier: NCT01024478.
Acquisition of coronary MRA was successfully completed in 235 of 272 (86%) patients with average imaging time of 9.5±1.6 minutes. The areas under the receiver-operator characteristic curve from MRA images according to vessel- and patient-based analyses were 0.90 (95% confidence interval [CI]: 0.88 to 0.95) and 0.88 (95% CI: 0.83 to 0.93), respectively. The sensitivity and specificity of MRA on per-patient basis were 91% and 80%, respectively.
Among patients who were scheduled to obtain conventional x-ray coronary angiography, we found that coronary MRA at 3.0T demonstrates high accuracy for detection of significant coronary artery stenosis. It warrants greater consideration as a suitable noninvasive method to exclude obstructive CAD.
National Basic Research Program 973 (grant no. 2010CB732600) from Ministry of Science and Technology, China; National Natural Science Foundation of China, grant number 30900355; National Institute of Health, grants numbers NIBIB EB002623 and NHLBI HL38698.
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Yang, Q., Li, K., Sun, B. et al. Assessment of coronary artery disease using 3.0 T magnetic resonance coronary angiography: a national multicenter trial. J Cardiovasc Magn Reson 15, E5 (2013). https://doi.org/10.1186/1532-429X-15-S1-E5
- Coronary Artery Disease
- Magnetic Resonance Angiography
- Coronary Artery Stenosis
- Obstructive Coronary Artery Disease
- Suspected Coronary Artery Disease