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Table 1 CMR Metrics of Fibrosis and Serum PICP levels

From: T1 measurements identify extracellular volume expansion in a genotyped hypertrophic cardiomyopathy population with and without left ventricular hypertrophy

  Control N=10 p-value* Control vs Preclinical Preclinical HCM N=30 p-value* Preclinical vs Overt Overt HCM N=37 p-value* Control vs Overt
ECV (range) 0.26 ± 0.01 (0.24-0.31) <0.001 0.33 ± 0.01 (0.23-0.38) <0.001 0.37 ± 0.01 (0.31-0.51) <0.001
ECV, excluding LGE 0.26 ± 0.01 <0.001 0.33 ± 0.01 <0.001 0.37 ± 0.01 <0.001
LGE present, % (#yes / #no) 0% (0/10)   0% (0/29)   78.4% (29/8)  
LGE, g 0 0.8 0 0.004 16.7 ± 4.9 0.003
LGE, % LV mass 0 0.7 0 0.0006 7.76 ± 1.96 (0.9-44.6%) 0.001
PICP, μg/L 63.08 ± 4.19 <0.001 83.81 ± 4.39 0.035 108.04 ± 9.81 <0.001
  1. Data are presented as means adjusted for family relations and age ± standard error *p values <0.017 are statistically significant and adjusted for age and family relations ECV = extracellular volume; LGE = late gadolinium enhancement; PICP = carboxy-terminal propeptide of procollagen type I