- Oral presentation
- Open Access
Feasibility of MRI attenuation correction in cardiac FDG-PET
© Lau et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Attenuation Correction
- Siemens Biograph
- Myocardial Glucose Metabolism
- Average SUVs
- Papillary Muscle Level
Simultaneous acquisition PET-MRI is a new technology that has the potential to significantly impact diagnostic patient care. Cardiac imaging using PET-MRI offers high signal resolution MRI images superimposed on PET metabolic functional assessment. Specifically, 18F-fluorodeoxyglucose (FDG) PET-MR has the potential to provide both anatomic scar tissue evaluation and information regarding myocardial glucose metabolism. While early brain and soft tissue data have demonstrated that PET specific uptake values (SUVs) obtained using MRI for attenuation correction (AC) are comparable to SUVs obtained using CT AC, SUV measurements of myocardial tissue have not been compared. The objective of this pilot study is to determine the reproducibility of SUVs obtained by PET imaging using an AC µ-map comprised of a dual echo VIBE Dixon MRI sequence instead of CT.
30 patients with no known cardiac history underwent full body PET-CT imaging (Siemens Biograph 40), followed by full-body simultaneous PET-MRI imaging (Siemens Biograph mMR). A single dose (10-15 mCi) of 18F-FDG radiotracer was injected on average 59 +/- 7 minutes prior to PET-CT image acquisition, and127 +/- 23 minutes prior to PET-MRI image acquisition. Images were whole body images acquired without cardiac gating. For PET-MR the AC µ-map was a dual echo VIBE Dixon sequence that separates water and fat (TE1/TE2 = 1.23 msec/2.46 msec, TR = 3.6 msec, left-right FOV = 500 mm, anterior-posterior FOV = 300 mm). Average SUVs were obtained by tracing the entire cross section of the left ventricular myocardium in the short axis of the heart at the papillary muscle level, using the syngo TRUE-D computer software (Siemens).
Myocardial PET SUVs measured using MRI as AC show excellent correlation to those obtained by standard PET-CT imaging. Future studies will focus on the optimization of cardiac-gated simultaneous PET-MRI image acquisition.
Mallinckrodt Institute of Radiology Departmental Funds.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.