Biventricular dimensions and function in pediatric sickle-cell disease and thalassemia major patients without cardiac iron

Table 1 LV parameters for and SCD and TM pediatric patient without cardiac iron overload, with differentiation for gender. All variables are expressed as mean ± SD with 95% confidence intervals in square brackets.

	SCD	TM	P	P adjusted for systolic BP	P adjusted for cardiac R2*	P adjusted for both covariates
*Males*
LV EDVI (ml/m ² )	104.7 ± 15.2 [99.5 - 109.9]	88.7 ± 11.0 [84.5 - 92.8]	<0.0001	<0.0001	<0.0001	<0.0001
LV ESVI (ml/m ² )	38.1 ± 7.4 [35.6 - 40.7]	31.6 ± 5.5 [29.5 - 33.6]	<0.0001	<0.0001	0.0003	<0.0001
LV SVI (ml/m ² )	66.6 ± 9.5 [63.3 - 69.8]	57.1 ± 6.5 [54.6 - 59.5]	<0.0001	<0.0001	<0.0001	<0.0001
LV EF (%)	63.8 ± 3.5 [62.6 - 65.0]	64.7 ± 2.8 [63.6 - 65.7]	0.286
LV MI (g/m ² )	83.5 ± 11.4 [79.1 - 87.9] (27 pts; 45 MRIs)	66.9 ± 7.0 [64.0 - 69.8] (24 pts; 59 MRIs)	<0.0001	<0.0001	<0.0001	<0.0001
LV CI (l/min/m2)	4.8 ± 0.6 [4.6 - 5.1] (32 pts; 55 MRIs)	4.5 ± 0.5 [4.4 - 4.7] (29 pts; 74 MRIs)	0.017
*Females*
LV EDVI (ml/m ² )	93.5 ± 9.6 [90.0 - 97.0]	81.4 ± 6.7 [78.4 - 84.4]	<0.0001	<0.0001	<0.0001	<0.0001
LV ESVI (ml/m ² )	36.0 ± 5.3 [34.0 - 37.9]	29.4 ± 3.8 [27.6 - 31.1]	<0.0001	<0.0001	<0.0001	<0.0001
LV SVI (ml/m ² )	57.5 ± 6.3 [55.2 - 59.8]	52.0 ± 4.2 [50.1 - 53.4]	0.0006	0.009
LV EF (%)	61.6 ± 3.5 [60.4 - 62.9]	64.1 ± 2.9 [62.8 - 65.4]	0.008
LV MI (g/m ² )	72.9 ± 8.9 [69.6 - 79.3] (28 pts; 60 MRIs)	62.8 ± 7.5 [60.4 - 66.1] (18 pts; 40 MRIs)	0.0001	0.0002
LV CI (l/min/m ² )	4.6 ± 0.6 [4.4 - 4.8] (72 MRIs)	4.2 ± 0.5 [3.9 - 4.4] (52 MRIs)	0.006

ISSN: 1532-429X