Table 1 LV parameters for and SCD and TM pediatric patient without cardiac iron overload, with differentiation for gender. All variables are expressed as mean ± SD with 95% confidence intervals in square brackets.

Males

LV EDVI (ml/m ² )

104.7 ± 15.2 [99.5 - 109.9]

88.7 ± 11.0 [84.5 - 92.8]

<0.0001

<0.0001

<0.0001

<0.0001

LV ESVI (ml/m ² )

38.1 ± 7.4 [35.6 - 40.7]

31.6 ± 5.5 [29.5 - 33.6]

<0.0001

<0.0001

0.0003

<0.0001

LV SVI (ml/m ² )

66.6 ± 9.5 [63.3 - 69.8]

57.1 ± 6.5 [54.6 - 59.5]

<0.0001

<0.0001

<0.0001

<0.0001

LV EF (%)

63.8 ± 3.5 [62.6 - 65.0]

64.7 ± 2.8 [63.6 - 65.7]

0.286

LV MI (g/m ² )

83.5 ± 11.4 [79.1 - 87.9] (27 pts; 45 MRIs)

66.9 ± 7.0 [64.0 - 69.8] (24 pts; 59 MRIs)

<0.0001

<0.0001

<0.0001

<0.0001

LV CI (l/min/m2)

4.8 ± 0.6 [4.6 - 5.1] (32 pts; 55 MRIs)

4.5 ± 0.5 [4.4 - 4.7] (29 pts; 74 MRIs)

0.017

Females

LV EDVI (ml/m ² )

93.5 ± 9.6 [90.0 - 97.0]

81.4 ± 6.7 [78.4 - 84.4]

<0.0001

<0.0001

<0.0001

<0.0001

LV ESVI (ml/m ² )

36.0 ± 5.3 [34.0 - 37.9]

29.4 ± 3.8 [27.6 - 31.1]

<0.0001

<0.0001

<0.0001

<0.0001

LV SVI (ml/m ² )

57.5 ± 6.3 [55.2 - 59.8]

52.0 ± 4.2 [50.1 - 53.4]

0.0006

0.009

LV EF (%)

61.6 ± 3.5 [60.4 - 62.9]

64.1 ± 2.9 [62.8 - 65.4]

0.008

LV MI (g/m ² )

72.9 ± 8.9 [69.6 - 79.3] (28 pts; 60 MRIs)

62.8 ± 7.5 [60.4 - 66.1] (18 pts; 40 MRIs)

0.0001

0.0002

LV CI (l/min/m ² )

4.6 ± 0.6 [4.4 - 4.8] (72 MRIs)

4.2 ± 0.5 [3.9 - 4.4] (52 MRIs)

0.006