Ex vivo signatures of myocardial edema by in vivo T2-CMR in a novel large animal model of NSTE-ACS
© Chang et al; licensee BioMed Central Ltd. 2013
Published: 30 January 2013
Non ST-segment acute coronary syndromes (NSTE-ACS) comprise 70% of all ACS. Difficulty in recognizing which patients have myocardium at risk contributes to heterogeneity in NSTE-ACS management, leading to poor outcomes compared to ST-elevation myocardial infarction (STEMI). To date, lack of suitable animal models has impeded progress in optimizing care. We developed a novel canine model to mimic NSTE-ACS, and evaluated ex vivo myocardial characteristics in the context of in vivo T2-CMR that may identify at-risk and salvageable regions.
Five mongrel dogs underwent thoracotomy to create a left circumflex coronary artery stenosis without complete occlusion and to place epicardial pacing electrodes, and two dogs underwent sham thoracotomy. Pacing the animals with circumflex stenosis produced ST depression that resolved upon termination of pacing. Pre- and post-pacing CMR was performed in anesthetized, intubated animals on a 1.5 Tesla scanner with T2 mapping and late gadolinium enhancement (LGE) scans.
These preliminary studies suggest that in vivo T2-CMR can identify regions of that heart with potentially reversible myocardial and mitochondrial injury in a novel canine model of NSTE-ACS.
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