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Serial T2-mapping to quantitatively monitor resorption of myocardial edema following acute myocardial infarction
Journal of Cardiovascular Magnetic Resonance volume 15, Article number: P179 (2013)
Currently, myocardial edema monitoring after acute myocardial infarction (AMI) is based on visualization of the region with increased signal-intensity on T2-weighted images. T2-mapping is a promising novel cardiac magnetic resonance imaging (CMR) technique to quantitatively assess myocardial edema. The purpose of the study was to quantitatively evaluate resorption of myocardial edema following AMI using T2-mapping.
CMR (1.5 Tesla Philips Achieva) was performed in 20 patients within seven days after a reperfused AMI (Baseline) and at one, three and six months follow-up, respectively. A free-breathing, navigator-gated multi-echo sequence was used for T2-mapping. T2-maps were calculated from fifteen echoes using a dedicated plug-in written for OsiriX software. Serial T2 values were assessed using a six-segment model (Figure). Infarcted and remote segments were defined by using information from corresponding late-enhancement images (Figure).
A significant decrease of the T2 time was found in infarcted segments from baseline to one month follow-up (82±19 vs. 70±7 ms; p<0.05), but not between one and three (70±7 vs. 62±8; p=ns) or three and six (62±8 vs. 62±5 ms; p=ns) month follow-up. Identical T2 times were found in remote segments at baseline, one, three and six month follow-up (61±6 vs. 61±5 vs. 59±7 vs. 58±2 ms; p=ns). The T2infarct/T2remote ratio decreased from baseline to one month follow-up (1.34±0.26 vs. 1.15±0.10; p<0.05) and from one to three month follow-up (1.15±0.10 vs. 1.04±0.06; p=0.05). No significant change was found for the T2infarct/T2remote ratio from three to six month follow-up (1.04±0.06 vs. 1.07±0.09; p=ns).
Serial T2-mapping enables monitoring of edema resorption following acute myocardial infarction. The magnitude of edema resorption occurs in the first month after AMI and the T2 values normalize within 3 months after AMI. Thereafter, no further T2 time reduction is observed.
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Lund, G., Muellerleile, K., Bannas, P. et al. Serial T2-mapping to quantitatively monitor resorption of myocardial edema following acute myocardial infarction. J Cardiovasc Magn Reson 15 (Suppl 1), P179 (2013). https://doi.org/10.1186/1532-429X-15-S1-P179
- Public Health
- Magnetic Resonance Imaging
- Myocardial Infarction
- Acute Myocardial Infarction
- Cardiac Magnetic Resonance