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- Open Access
Serial T2-mapping to quantitatively monitor resorption of myocardial edema following acute myocardial infarction
© Lund et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Public Health
- Magnetic Resonance Imaging
- Myocardial Infarction
- Acute Myocardial Infarction
- Cardiac Magnetic Resonance
Currently, myocardial edema monitoring after acute myocardial infarction (AMI) is based on visualization of the region with increased signal-intensity on T2-weighted images. T2-mapping is a promising novel cardiac magnetic resonance imaging (CMR) technique to quantitatively assess myocardial edema. The purpose of the study was to quantitatively evaluate resorption of myocardial edema following AMI using T2-mapping.
A significant decrease of the T2 time was found in infarcted segments from baseline to one month follow-up (82±19 vs. 70±7 ms; p<0.05), but not between one and three (70±7 vs. 62±8; p=ns) or three and six (62±8 vs. 62±5 ms; p=ns) month follow-up. Identical T2 times were found in remote segments at baseline, one, three and six month follow-up (61±6 vs. 61±5 vs. 59±7 vs. 58±2 ms; p=ns). The T2infarct/T2remote ratio decreased from baseline to one month follow-up (1.34±0.26 vs. 1.15±0.10; p<0.05) and from one to three month follow-up (1.15±0.10 vs. 1.04±0.06; p=0.05). No significant change was found for the T2infarct/T2remote ratio from three to six month follow-up (1.04±0.06 vs. 1.07±0.09; p=ns).
Serial T2-mapping enables monitoring of edema resorption following acute myocardial infarction. The magnitude of edema resorption occurs in the first month after AMI and the T2 values normalize within 3 months after AMI. Thereafter, no further T2 time reduction is observed.
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