Skip to main content

Reverse remodeling after coronary revascularization in patients with ischemic heart disease: focused on change of infarct scar


We sought to evaluate the serial change of enhanced necrotic tissue and nonenhanced noninfarct tissue after surgical revascularization in patients with ischemic left ventricular (LV) dysfunction using magnetic resonance (MR) imaging as a quantification tool.

figure 1

Figure 1

figure 2

Figure 2


Twenty-four patients with severe LV dysfunction {ejection fraction (EF) <35% on echocardiography} underwent before and more than 6 months after surgical revascularization. The following variables were measured: LV volumes, EF, mass, absolute and relative infarction size, transmural extent of infarction, and wall thickness. All patients were classified into two groups: group I, presence of revere remodeling after revascularization; group II, absence of reverse remodeling group. A reduction of 10% or more in end-diastole and end-systole volumes were considered presence of reverse remodeling. Variables were compared between preoperative and postoperative MR scans in each group.


Of 24, 20 patients showed reverse remodeling. In group I, EF (28.8±6.6% vs. 40.6±7.8, p<0.0001) was significantly improved. Group I showed no change of absolute infarction size (17.3±10.9 g vs. 17.5±10.4 g, p=0.8) but significant increase in relative infarction size (21.0±13.7% vs. 26.5±19.4%, p=0.01) because of reduction of myocardial mass after revascularization. Significant increase in regional transmural extent (35.2±22.8% vs. 39.6±24.2%, p<0.0001) and thickness of enhanced tissue (4.2±1.5 mm vs. 5.9±1.8 mm, p<0.0001) were found in group I. However, thicknesses of nonenhanced rim and remote myocardium were not changed. There were no significant changes in all variables in group II.


MR imaging demonstrated the significant increase in depth of necrotic tissue during the reverse remodeling. It can be explained by reverse slippage of the necrotic tissue. Transmural extent of necrotic tissue in patients with severe LV remodeling may be underestimated, resulting in false positive interpretation of viability.



Author information

Authors and Affiliations


Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and permissions

About this article

Cite this article

Park, EA., Lee, W., Kim, Y.K. et al. Reverse remodeling after coronary revascularization in patients with ischemic heart disease: focused on change of infarct scar. J Cardiovasc Magn Reson 15 (Suppl 1), P183 (2013).

Download citation

  • Published:

  • DOI: