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- Open Access
First-pass myocardial stress perfusion MRI using k-t BLAST at an open MR-system: initial results in comparison to FFR measurements
© Strach et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Fractional Flow Reserve
- Significant Coronary Artery Disease
- Stress Perfusion
- Conventional Coronary Angiography
- Significant Coronary Artery Stenosis
Therefore, the aim of our study was to evaluate 1) feasibility of adenosine stress perfusion (ASP) MRI using k-t BLAST in patients with suspected or known CAD in a clinical setting as well as 2) Contrast Enhancement Ratio (CER) and image quality at an open MR system.
58 patients (18 female, 40 male; 62+/-13 years) with known or suspected CAD underwent a standard ASP at an open Panorama HFO 1.0 Tesla System (Philips Healthcare, Best, Netherlands). First-pass perfusion was acquired using a k-space segmented T1-weighted gradient-echo sequence (in-plane resolution 3x3 mm2, slice thickness 10 mm, k-t factor 3.5) at rest and during i.v. adenosine administration (140 µg/kg BW for 4 minutes). The CER (=myocardial peak signal - myocardial baseline signal/myocardial baseline signal) for stress perfusion studies and overall image quality (4-point grading scale: 4: excellent; 1: non-diagnostic) both of rest and stress examinations were assessed. A semiquantitative analysis of dark rim artifacts was performed and transmural extent (1:<25%; 2: 25-49%; 3:50-74%; 4: 75-100%) evaluated. Hemodynamically significant CAD was defined as fractional flow reserve <0.8 using conventional coronary angiography.
All examinations (n=58/58) were completed successfully. CER of stress perfusion was 2.52+/-1.14. Overall image quality was 3.37+/-0.67 for rest and 3.54+/-0.66 for stress perfusion. Dark rim artefacts appeared in 129 of 928 slices (14%) and were predominately subendocardial (1:93/129, 72%; 2:15/129, 12%; 3:12/129, 9%; 4:9/129, 7%). Sensitivity and specificity for detection of significant CAD was 91% and 82%, respectively.
First-pass stress perfusion MR imaging at an open 1.0 T MR-system is feasible in a clinical setting and yields promising results for the detection of significant coronary artery stenosis. Additionally, using k-t BLAST ASP provides good image quality and contrast, while preserving good temporal and spatial resolution.
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