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CEMRA in neonatal and pediatric congenital vascular diseases at 1.5T and 3.0T: comparison of an intravascular contrast agent (Gadofosveset) with an extracellular agent (Gadopentetate Dimeglumine)


The comparison of gadofosveset (Ablavar, Lantheus Medical) at a dose of 0.06 mmol /kg with gadopentetate dimeglumine (Magnevist, Bayer-Schering Inc.) at a dose of 0.2 mmol /kg for CEMRA in pediatric patients with complex congenital heart disease (CCHD) at 1.5T and 3.0T.


Twenty-eight pediatric patients with CCHD underwent CEMRA at 3.0T (n=16) or at 1.5T (n=12). Sixteen patients were imaged with gadofosveset; 9 at 3.0T (age 1.00 ± 1.58 months; weight 2.38 ± 1.13 kg) and 7 at 1.5T (age 8.00 ± 7.83 months; weight 5.06 ± 3.09 kg). Twelve patients were imaged with gadopentetate; 7 at 3.0T (age 1.00 ± 1.41 months; weight 3.02 ± 1.59 kg) and 5 at 1.5T (age 6.60 ± 8.62 months; weight 5.23 ± 2.93 kg). High resolution CEMRA was performed in two phases with strictly comparable imaging parameters, acquisition times and contrast agent infusion periods. Two independent observers scored the studies blindly on a four point scale for image quality, artifacts and vessel definition.


At 3.0T, overall image quality (IQ) was good to excellent (3<=IQ<=4) in all patients and similar for gadofosveset and gadopentate. At 1.5T, IQ was also good to excellent, but higher for gadofosveset than gadopentetate. Cardiac motion or pulsation artifact was found in all studies at both field strengths but appeared more severe at 3.0T than 1.5T. Parallel acquisition artifact was noted in all studies at 3.0T, but in no studies at 1.5T. Vessel definition scores were higher for gadofosveset at both field strengths and both contrast phases, but lower for gadopentetate in the venous phase at 3.0T and in both phases at 1.5T. SNR and CNR was higher at 3.0T than 1.5T in the aortic arch, pulmonary artery, inferior vena cava and superior vena cava. SNR and CNR was higher for gadofosveset than gadopentetate during the arterial phase in the aortic arch and pulmonary artery.


Both gadofosveset and gadopentetate support reliable and high quality CEMRA at 1.5T and 3.0T in children with complex congenital vascular diseases. However, gadofosveset scored higher than gadopentetate with respect to image quality, vessel definition, SNR and CNR at less than one third the dose of Gadolinium. Furthermore, the prolonged intravascular residence time of gadofosveset enabled the maximum duration of breath holding to be halved relative to gadopentetate, while maintaining excellent enhancement in the venous phase.


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Figure 1
figure 1

3D volume rendered reconstruction in a 4 day old neonate with interrupted aortic arch.

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Khan, S.N., DaSilva, C. & Finn, J.P. CEMRA in neonatal and pediatric congenital vascular diseases at 1.5T and 3.0T: comparison of an intravascular contrast agent (Gadofosveset) with an extracellular agent (Gadopentetate Dimeglumine). J Cardiovasc Magn Reson 15 (Suppl 1), P284 (2013).

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