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Table 3 Endpoint 1 – cardiac death, aborted SCD, appropriate ICD discharge

From: Cardiovascular magnetic resonance risk stratification in patients with clinically suspected myocarditis

  Endpoint 1 No endpoint p-value OR (95% - CI)
  (n = 10) (n = 395)   
Age [years] 66.1 (59.2-68.6) 47.7 (36.4-60.2) <0.01  
Gender, female 4 (40) 173 (43.8) 0.81 0.86 (0.24-3.08)
Referring physician     
 Inpatients 7(70) 215 (54.4) 0.31 1.99 (0.51-7.82)
 Outpatients referred by cardiologists 3 (30) 151 (38.2) 0.60 0.69 (0.18-2.72)
 Outpatients referred by general practitioners 0 29 (7.3) 0.37  
Primary cardiac symptoms leading to CMR     
 Reduced LVEF 6 (60) 76 (19.2) <0.01 6.30 (1.73-22.86)
 Pericardial effusion 0 (0) 6 (1.5) 0.69  
 ECG abnormality 3 (30) 128 (32.4) 0.87 0.89 (0.23-3.51)
 Palpitations 1 (10) 91 (23) 0.33 0.37 (0.05-2.97)
 Dyspnea 6 (60) 131 (33.2) 0.08 3.02 (0.84-10.90)
 Angina/Chest pain 4 (40) 213 (53.9) 0.38 0.57 (0.16-2.05)
 Abnormal fatigue 2 (20) 94 (23.9) 0.78 0.80 (0.17-3.82)
 Wall motion abnormality 0 17 (4.3) 0.50  
 Ventricular arrythmias/Extrasystoles 0 45 (11.4) 0.26  
 Aborted SCD 0 6 (1.5) 0.69  
Viral prodrome/history of infectious symptoms 2 (20) 128 (32.4) 0.41 0.52 (0.11-2.49)
Atrial fibrillation 2 (20) 48 (12.2) 0.46 1.80 (0.37-8.74)
Elevated troponin 0 38 (9.6) 0.30  
EMB performed 6 (60) 72 (19.5) <0.01 6.21 (1.71-22.58)
 Histopathological myocarditis in EMB 4 (66.7) 49 (69) 0.91 0.90 (0.15-5.27)
 CMR imaging parameters     
 LVEF [%] 34.5 (22.0-43.0) 63.0 (56–69) <0.0001  
 LV-EDV [ml] 197 (144–269) 136 (110–163) <0.01  
 LV-ESV [ml] 127 (86–188) 49 (36–68) <0.001  
 LVEDD [mm] 61 (54–65) 50 (46–54) <0.01  
 Pericardial effusion present 6 (60) 70 (17.7) <0.01 6.94 (1.91-25.25)
 LGE present 8 (80.0) 106 (27) <0.001 10.83 (2.26-51.82)
Final diagnosis based on CMR     
 No cardiac pathology 0 225 (57) <0.001  
 Myocarditis 8 (80) 108 (27.3) <0.001 10.63 (2.22-50.85)
 Other cardiac pathology 2 (20) 61 (15.4) 0.69 1.37 (0.28-6.60)
Medication     
 Betablockers at follow-up 6 (75) 125 (34.3) <0.05 5.74 (1.14-28.84)
 ACEI/ARB at follow-up 7 (87.5) 100 (27.5) <0.001 18.48 (2.25-152.1)
  1. Values shown are n (%) or medians (25th -75th percentiles) Abbreviations are the same as in Table 1.