Table 3 Endpoint 1 – cardiac death, aborted SCD, appropriate ICD discharge
Endpoint 1 | No endpoint | p-value | OR (95% - CI) | |
|---|---|---|---|---|
(n = 10) | (n = 395) | |||
Age [years] | 66.1 (59.2-68.6) | 47.7 (36.4-60.2) | <0.01 | |
Gender, female | 4 (40) | 173 (43.8) | 0.81 | 0.86 (0.24-3.08) |
Referring physician | ||||
Inpatients | 7(70) | 215 (54.4) | 0.31 | 1.99 (0.51-7.82) |
Outpatients referred by cardiologists | 3 (30) | 151 (38.2) | 0.60 | 0.69 (0.18-2.72) |
Outpatients referred by general practitioners | 0 | 29 (7.3) | 0.37 | |
Primary cardiac symptoms leading to CMR | ||||
Reduced LVEF | 6 (60) | 76 (19.2) | <0.01 | 6.30 (1.73-22.86) |
Pericardial effusion | 0 (0) | 6 (1.5) | 0.69 | |
ECG abnormality | 3 (30) | 128 (32.4) | 0.87 | 0.89 (0.23-3.51) |
Palpitations | 1 (10) | 91 (23) | 0.33 | 0.37 (0.05-2.97) |
Dyspnea | 6 (60) | 131 (33.2) | 0.08 | 3.02 (0.84-10.90) |
Angina/Chest pain | 4 (40) | 213 (53.9) | 0.38 | 0.57 (0.16-2.05) |
Abnormal fatigue | 2 (20) | 94 (23.9) | 0.78 | 0.80 (0.17-3.82) |
Wall motion abnormality | 0 | 17 (4.3) | 0.50 | |
Ventricular arrythmias/Extrasystoles | 0 | 45 (11.4) | 0.26 | |
Aborted SCD | 0 | 6 (1.5) | 0.69 | |
Viral prodrome/history of infectious symptoms | 2 (20) | 128 (32.4) | 0.41 | 0.52 (0.11-2.49) |
Atrial fibrillation | 2 (20) | 48 (12.2) | 0.46 | 1.80 (0.37-8.74) |
Elevated troponin | 0 | 38 (9.6) | 0.30 | |
EMB performed | 6 (60) | 72 (19.5) | <0.01 | 6.21 (1.71-22.58) |
Histopathological myocarditis in EMB | 4 (66.7) | 49 (69) | 0.91 | 0.90 (0.15-5.27) |
CMR imaging parameters | ||||
LVEF [%] | 34.5 (22.0-43.0) | 63.0 (56–69) | <0.0001 | |
LV-EDV [ml] | 197 (144–269) | 136 (110–163) | <0.01 | |
LV-ESV [ml] | 127 (86–188) | 49 (36–68) | <0.001 | |
LVEDD [mm] | 61 (54–65) | 50 (46–54) | <0.01 | |
Pericardial effusion present | 6 (60) | 70 (17.7) | <0.01 | 6.94 (1.91-25.25) |
LGE present | 8 (80.0) | 106 (27) | <0.001 | 10.83 (2.26-51.82) |
Final diagnosis based on CMR | ||||
No cardiac pathology | 0 | 225 (57) | <0.001 | |
Myocarditis | 8 (80) | 108 (27.3) | <0.001 | 10.63 (2.22-50.85) |
Other cardiac pathology | 2 (20) | 61 (15.4) | 0.69 | 1.37 (0.28-6.60) |
Medication | ||||
Betablockers at follow-up | 6 (75) | 125 (34.3) | <0.05 | 5.74 (1.14-28.84) |
ACEI/ARB at follow-up | 7 (87.5) | 100 (27.5) | <0.001 | 18.48 (2.25-152.1) |