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Table 3 Factors influencing the accuracy of T1-measurement using inversion and/or saturation recovery methods

From: T1-mapping in the heart: accuracy and precision

Protocol parameters Matrix size • Underestimation in T1 depends on the protocol parameters
Parallel imaging
Partial Fourier • Precision depends on the sampling strategy
Flip angle
Echo-spacing (BW & TR) • Partial volume errors depend on the spatial resolution and slice thickness
# images & acquisition strategy
  Inversion times
  Recovery times
Raw filter
Sequence design Slice profile • T1 measurement accuracy is influenced by the sequence design
Inversion pulse efficiency & BW
SSFP steady state run-up
Scanner adjustments Shim • Off-resonance causes both regional and global underestimation of T1
Center frequency adjustment • Short z-FOV influences recovery time for inflowing blood
B1 transmit ampl (flip angle) • Scan to scan variation affects reproducibility
Fit model 2 vs 3 parameters • Fitting additional parameters worsens precision
Multi-fit MagIR vs PSIR
Tissue characteristics T2 • Tissue characteristics influence the apparent inversion recovery
Fatty infiltration • Partial volume effects are an artifact and may contaminate measurements
Patient Heart rate • Loss of spatial resolution due to motion increases the partial volume problem
Respiratory motion