Biopsy-based calibration of T2* magnetic resonance for estimation of liver iron concentration and comparison with R2 Ferriscan

Table 1 Comparison of LIC calibration methods

Authors	Method	Liver slice thickness	ROI size	ROI number	Localization within liver	TE, step [ms]	TR [ms]	Breath-hold	Background noise reduction	Notes
St Pierre et al.[14]	T2	5 mm, 5 mm gap	Whole liver	1	Largest axial slice	6-18, 3	2500	Single	Voxel intensity smoothing	SSE
Wood et al.[17]	T2*	15 mm	Whole liver	1	Mid-hepatic slice	0.8-4.8, 0.25	25	Single	Variable offset	Single echo gradient echo
Wood et al.[17]	T2	15 mm, 5 mm gap	Whole liver	4	Entire liver boundary without obvious hilar vessels	3.5-30, nd	nd	Single	Variable offset	Single echo 120°-120° Hahn echo
Hankins et al.[18]	T2*	10 mm	Small, variable	1	Transverse slice, at the level of main portal vein origin, excluding vessels and bile ducts	1.1-17.3, 0.8	nd	One per TE	Truncation	Multiecho gradient echo
McCarville et al.[34]	T2*	10 mm	Whole liver	1	Transverse, at the level of main portal vein origin	1.1-17.3, 0.8	200	Single	nd	Multiecho gradient echo
McCarville et al.[34]	T2*	10 mm	Small, variable	1	Right lobe, excluding vessels and bile ducts	1.1-17.3, 0.8	200	Single	nd	Multiecho gradient echo
Gandon et al.[15]	T2*	10 mm	Small, variable	3	Right lobe	4-21, nd	120	nd	Saturation threshold defined	GRE
Garbowski et al.	T2*	10 mm	Small, variable	3	Transverse mid-hepatic slice right lobe, excluding vessels and bile ducts	0.93-16, nd	nd	Single	Truncation	Multiecho gradient echo

All scanners are 1.5 T; TE, echo time; TR, repetition time; SSE, single echo spin echo; GRE, gradient recalled echo; ROI, region of interest; nd, no data.

ISSN: 1532-429X