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Table 1 Comparison of LIC calibration methods

From: Biopsy-based calibration of T2* magnetic resonance for estimation of liver iron concentration and comparison with R2 Ferriscan

Authors

Method

Liver slice thickness

ROI size

ROI number

Localization within liver

TE, step [ms]

TR [ms]

Breath-hold

Background noise reduction

Notes

St Pierre et al.[14]

T2

5 mm, 5 mm gap

Whole liver

1

Largest axial slice

6-18, 3

2500

Single

Voxel intensity smoothing

SSE

Wood et al.[17]

T2*

15 mm

Whole liver

1

Mid-hepatic slice

0.8-4.8, 0.25

25

Single

Variable offset

Single echo gradient echo

Wood et al.[17]

T2

15 mm, 5 mm gap

Whole liver

4

Entire liver boundary without obvious hilar vessels

3.5-30, nd

nd

Single

Variable offset

Single echo 120°-120° Hahn echo

Hankins et al.[18]

T2*

10 mm

Small, variable

1

Transverse slice, at the level of main portal vein origin, excluding vessels and bile ducts

1.1-17.3, 0.8

nd

One per TE

Truncation

Multiecho gradient echo

McCarville et al.[34]

T2*

10 mm

Whole liver

1

Transverse, at the level of main portal vein origin

1.1-17.3, 0.8

200

Single

nd

Multiecho gradient echo

McCarville et al.[34]

T2*

10 mm

Small, variable

1

Right lobe, excluding vessels and bile ducts

1.1-17.3, 0.8

200

Single

nd

Multiecho gradient echo

Gandon et al.[15]

T2*

10 mm

Small, variable

3

Right lobe

4-21, nd

120

nd

Saturation threshold defined

GRE

Garbowski et al.

T2*

10 mm

Small, variable

3

Transverse mid-hepatic slice right lobe, excluding vessels and bile ducts

0.93-16, nd

nd

Single

Truncation

Multiecho gradient echo

  1. All scanners are 1.5 T; TE, echo time; TR, repetition time; SSE, single echo spin echo; GRE, gradient recalled echo; ROI, region of interest; nd, no data.