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Table 1 Comparison of LIC calibration methods

From: Biopsy-based calibration of T2* magnetic resonance for estimation of liver iron concentration and comparison with R2 Ferriscan

Authors Method Liver slice thickness ROI size ROI number Localization within liver TE, step [ms] TR [ms] Breath-hold Background noise reduction Notes
St Pierre et al.[14] T2 5 mm, 5 mm gap Whole liver 1 Largest axial slice 6-18, 3 2500 Single Voxel intensity smoothing SSE
Wood et al.[17] T2* 15 mm Whole liver 1 Mid-hepatic slice 0.8-4.8, 0.25 25 Single Variable offset Single echo gradient echo
Wood et al.[17] T2 15 mm, 5 mm gap Whole liver 4 Entire liver boundary without obvious hilar vessels 3.5-30, nd nd Single Variable offset Single echo 120°-120° Hahn echo
Hankins et al.[18] T2* 10 mm Small, variable 1 Transverse slice, at the level of main portal vein origin, excluding vessels and bile ducts 1.1-17.3, 0.8 nd One per TE Truncation Multiecho gradient echo
McCarville et al.[34] T2* 10 mm Whole liver 1 Transverse, at the level of main portal vein origin 1.1-17.3, 0.8 200 Single nd Multiecho gradient echo
McCarville et al.[34] T2* 10 mm Small, variable 1 Right lobe, excluding vessels and bile ducts 1.1-17.3, 0.8 200 Single nd Multiecho gradient echo
Gandon et al.[15] T2* 10 mm Small, variable 3 Right lobe 4-21, nd 120 nd Saturation threshold defined GRE
Garbowski et al. T2* 10 mm Small, variable 3 Transverse mid-hepatic slice right lobe, excluding vessels and bile ducts 0.93-16, nd nd Single Truncation Multiecho gradient echo
  1. All scanners are 1.5 T; TE, echo time; TR, repetition time; SSE, single echo spin echo; GRE, gradient recalled echo; ROI, region of interest; nd, no data.
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