Figure 8

Perfluorocarbon-labeled microcapsules for X-ray visible cell tracking by CT. (A) Cone beam CT acquired on a flat-panel X-ray angiographic system (Axiom Artis, Siemens AG, Forchheim, Germany) demonstrating the detection of four perfluorooctylbromide (PFOB) injection sites in a rabbit medial thigh, while unlabeled capsules in the left thigh are not detectable. (B) 19 F MRI of the same rabbit showing one-to-one correspondence to the injection location on cone beam CT. (C) Co-registering of threshold cone beam CT image of a rabbit with 6 PFOB Caps injection sites (gray) and postmortem 3D rendering volume of each injection sites (color) demonstrating the location of opacities on cone beam CT image is representative of PFOB Caps injections. Registration error for each injection site from a representative rabbit is shown. Reprinted with permission from Fu et al.[172].